rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3-4
|
pubmed:dateCreated |
1999-3-3
|
pubmed:abstractText |
Since the discovery of the CD34 stem/progenitor cell antigen, considerable progress has been made in further purifying human lymphohematopoietic stem cells (HSC). These studies have identified a number of antigens which can be targeted to subfractionate the CD34+ cell population. In particular, several lines of evidence suggest that the rare CD38(-)subpopulation of CD34+ cells may be enriched in HSC. This review briefly summarizes relevant knowledge concerning the CD38 molecule and the results of in vitro and in vivo studies of CD34+38(-)cells. Possible clinical uses for purified CD34+38(-)cells are outlined.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP-ribosyl Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD38,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CD38 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NAD Nucleosidase
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1042-8194
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
31
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
285-93
|
pubmed:dateRevised |
2005-11-17
|
pubmed:meshHeading |
pubmed-meshheading:9869192-ADP-ribosyl Cyclase,
pubmed-meshheading:9869192-Antigens, CD,
pubmed-meshheading:9869192-Antigens, CD34,
pubmed-meshheading:9869192-Antigens, CD38,
pubmed-meshheading:9869192-Antigens, Differentiation,
pubmed-meshheading:9869192-Hematopoiesis,
pubmed-meshheading:9869192-Hematopoietic Stem Cells,
pubmed-meshheading:9869192-Humans,
pubmed-meshheading:9869192-Membrane Glycoproteins,
pubmed-meshheading:9869192-NAD+ Nucleosidase
|
pubmed:year |
1998
|
pubmed:articleTitle |
Biology of CD34+CD38- cells in lymphohematopoiesis.
|
pubmed:affiliation |
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. novelenm @ welchlink.welch.jhu.edu
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pubmed:publicationType |
Journal Article,
Review
|