Linked Life Data

9865533

Source:http://linkedlifedata.com/resource/pubmed/id/9865533

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-4-13
pubmed:abstractText
Improvement of endothelial function has been implicated in the cardioprotective effects of estrogens in women. In isolated human coronary arteries, we investigated whether 17beta-estradiol affects endothelium-dependent responses to bradykinin, an endothelium-derived vasodilator locally produced by endothelial cells. Concentration-response curves to bradykinin (0.03-300 nM) or nitroglycerine (0.01-1 microM) were obtained before and after 30 min of incubation with 17beta-estradiol (3 microM) or solvent control (ethanol 0.2% vol/vol). Incubation with 17beta-estradiol enhanced relaxations to bradykinin (from 43 +/- 6 to 83 +/- 3%, P < 0.0001) but not those to nitroglycerine (n.s.). Improvement of bradykinin-mediated endothelium-dependent relaxation may represent a novel mechanism contributing to the cardioprotective effects of estrogen in women.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
362
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
17Beta-estradiol acutely improves endothelium-dependent relaxation to bradykinin in isolated human coronary arteries.
pubmed:affiliation
Department of Medicine, Hannover Medical School, Germany. matthiasbarton@compuserve.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't