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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1999-2-2
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pubmed:abstractText |
It has been proposed that Streptomyces malonyl CoA: holo acyl carrier protein transacylases (MCATs) provide a link between fatty acid and polyketide biosynthesis. Two recent studies have provided evidence that the presence of MCAT is essential for polyketide synthesis to proceed in reconstituted minimal polyketide synthases (PKSs). In contrast to this, we previously showed that the holo acyl carrier proteins (ACPs) from type II PKSs are capable of catalytic self-malonylation in the presence of malonyl CoA, which suggests that MCAT might not be necessary for polyketide biosynthesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acyl-Carrier Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Acyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid Synthetase Complex...,
http://linkedlifedata.com/resource/pubmed/chemical/Malonates,
http://linkedlifedata.com/resource/pubmed/chemical/Malonyl Coenzyme A,
http://linkedlifedata.com/resource/pubmed/chemical/Polyketide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/fabD protein, E coli,
http://linkedlifedata.com/resource/pubmed/chemical/malonic acid,
http://linkedlifedata.com/resource/pubmed/chemical/polyketide beta-ketoacylsynthase
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
699-711
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9862793-Acyl-Carrier Protein S-Malonyltransferase,
pubmed-meshheading:9862793-Acyltransferases,
pubmed-meshheading:9862793-Bacterial Proteins,
pubmed-meshheading:9862793-Catalysis,
pubmed-meshheading:9862793-Chromatography, High Pressure Liquid,
pubmed-meshheading:9862793-Cloning, Molecular,
pubmed-meshheading:9862793-Escherichia coli,
pubmed-meshheading:9862793-Escherichia coli Proteins,
pubmed-meshheading:9862793-Fatty Acid Synthetase Complex, Type II,
pubmed-meshheading:9862793-Kinetics,
pubmed-meshheading:9862793-Malonates,
pubmed-meshheading:9862793-Malonyl Coenzyme A,
pubmed-meshheading:9862793-Polyketide Synthases,
pubmed-meshheading:9862793-Streptomyces
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pubmed:year |
1998
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pubmed:articleTitle |
MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor.
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pubmed:affiliation |
School of Chemistry University of Bristol Cantock's Close Bristol BS8 1TS UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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