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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1999-1-11
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pubmed:abstractText |
Fanconi anemia (FA) is an autosomal recessive disorder characterized by skeletal abnormalities, pancytopenia and a marked predisposition to cancer. FA cells exhibit chromosomal instability and hypersensitivity towards oxygen and cross-linking agents such as diepoxybutane and mitomycin C. An increased level of reactive oxygen intermediates and an elevation of 8-oxoguanine in FA cells point to a defective oxygen metabolism in FA cells. We investigated the repair activity of oxidatively damaged DNA in lymphoblastoid cells from FA patients of complementation groups A-E. The repair activity for oxidatively damaged DNA was significantly reduced in lymphoblastoid cell lines of complementation groups B-E. Complementation of the FA-C cell line with the wild type FA-C gene restored the repair activity to normal. This indicates that the FA-C protein participates in the repair of oxidatively damaged DNA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
440
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9862435-Cell Cycle Proteins,
pubmed-meshheading:9862435-Cell Line,
pubmed-meshheading:9862435-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:9862435-DNA, Superhelical,
pubmed-meshheading:9862435-DNA Damage,
pubmed-meshheading:9862435-DNA Repair,
pubmed-meshheading:9862435-DNA-Binding Proteins,
pubmed-meshheading:9862435-Electrophoresis, Agar Gel,
pubmed-meshheading:9862435-Fanconi Anemia,
pubmed-meshheading:9862435-Fanconi Anemia Complementation Group Proteins,
pubmed-meshheading:9862435-Genes, Reporter,
pubmed-meshheading:9862435-Humans,
pubmed-meshheading:9862435-Lymphocytes,
pubmed-meshheading:9862435-Nuclear Proteins,
pubmed-meshheading:9862435-Oxidative Stress,
pubmed-meshheading:9862435-Plasmids,
pubmed-meshheading:9862435-Potassium Permanganate,
pubmed-meshheading:9862435-Proteins,
pubmed-meshheading:9862435-Transfection
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pubmed:year |
1998
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pubmed:articleTitle |
Involvement of the Fanconi anemia protein FA-C in repair processes of oxidative DNA damages.
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pubmed:affiliation |
Institute of Biochemistry, Free University Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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