| pubmed-article:9862237 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9862237 | lifeskim:mentions | umls-concept:C0026565 | lld:lifeskim |
| pubmed-article:9862237 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:9862237 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:9862237 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:9862237 | lifeskim:mentions | umls-concept:C0016640 | lld:lifeskim |
| pubmed-article:9862237 | lifeskim:mentions | umls-concept:C0681814 | lld:lifeskim |
| pubmed-article:9862237 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9862237 | pubmed:dateCreated | 1999-3-22 | lld:pubmed |
| pubmed-article:9862237 | pubmed:abstractText | Age-specific mortality rates decelerate at older ages in both genetically homogenous and heterogeneous populations of Drosophila. One explanation proposed for deceleration is population heterogeneity. This hypothesis suggests that a population consists of sub-populations that differ in mortality characteristics and that the deceleration is the result of selective survival of stronger individuals. Here we describe an experiment that fractionates populations into several sub-populations without changing the physiological characteristics of the post-fractionated populations. Through a careful process of selection of Drosophila eggs, larvae, pupae and adults, we attempt to reduce as much as possible the degree of pre-adult, environmentally induced heterogeneity among individuals of a genetically identical cohort. We then ask whether such cohorts, when compared to non-fractionated populations, exhibit a lesser degree of mortality deceleration at advanced ages. From a total of 106 fractionated and control populations, consisting of 51331 individuals, 101 populations (93% of the fractionated populations and 100% of the control populations) exhibit a significant amount of mortality deceleration late in life. These observations suggest that environmental heterogeneity accrued during larval development is not a major factor contributing to mortality deceleration at older ages. | lld:pubmed |
| pubmed-article:9862237 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9862237 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9862237 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9862237 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9862237 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9862237 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9862237 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9862237 | pubmed:issn | 0047-6374 | lld:pubmed |
| pubmed-article:9862237 | pubmed:author | pubmed-author:CurtsingerJ... | lld:pubmed |
| pubmed-article:9862237 | pubmed:author | pubmed-author:KhazaeliA AAA | lld:pubmed |
| pubmed-article:9862237 | pubmed:author | pubmed-author:PletcherS DSD | lld:pubmed |
| pubmed-article:9862237 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9862237 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:9862237 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:9862237 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9862237 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9862237 | pubmed:pagination | 301-17 | lld:pubmed |
| pubmed-article:9862237 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9862237 | pubmed:meshHeading | pubmed-meshheading:9862237-... | lld:pubmed |
| pubmed-article:9862237 | pubmed:meshHeading | pubmed-meshheading:9862237-... | lld:pubmed |
| pubmed-article:9862237 | pubmed:meshHeading | pubmed-meshheading:9862237-... | lld:pubmed |
| pubmed-article:9862237 | pubmed:meshHeading | pubmed-meshheading:9862237-... | lld:pubmed |
| pubmed-article:9862237 | pubmed:meshHeading | pubmed-meshheading:9862237-... | lld:pubmed |
| pubmed-article:9862237 | pubmed:meshHeading | pubmed-meshheading:9862237-... | lld:pubmed |
| pubmed-article:9862237 | pubmed:meshHeading | pubmed-meshheading:9862237-... | lld:pubmed |
| pubmed-article:9862237 | pubmed:meshHeading | pubmed-meshheading:9862237-... | lld:pubmed |
| pubmed-article:9862237 | pubmed:meshHeading | pubmed-meshheading:9862237-... | lld:pubmed |
| pubmed-article:9862237 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9862237 | pubmed:articleTitle | The fractionation experiment: reducing heterogeneity to investigate age-specific mortality in Drosophila. | lld:pubmed |
| pubmed-article:9862237 | pubmed:affiliation | Department of Ecology, Evolution and Behavior, University of Minnesota, St. Paul 55108, USA. arabk001@maroon.tc.umn.edu | lld:pubmed |
| pubmed-article:9862237 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9862237 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9862237 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9862237 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9862237 | lld:pubmed |
