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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1999-2-25
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|
pubmed:abstractText |
S9788 is a triazineaminopiperidine derivative capable of reversing multidrug resistance (MDR) in vitro. In preclinical models S9788 was several fold more potent MDR inhibitor than verapamil or cyclosporine. At P-glycoprotein (Pgp) blocking concentrations, S9788 appeared to have only very little toxicity.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0923-7534
|
|
pubmed:author |
pubmed-author:BastianGG,
pubmed-author:BauerJJ,
pubmed-author:CernyTT,
pubmed-author:GerardBB,
pubmed-author:GirouxBB,
pubmed-author:LeyvrazSS,
pubmed-author:PaganoEE,
pubmed-author:SarkanyMM,
pubmed-author:SchläpferJJ,
pubmed-author:SessaCC,
pubmed-author:StuppRR
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|
pubmed:issnType |
Print
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1233-42
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|
pubmed:dateRevised |
2007-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:9862055-Adult,
pubmed-meshheading:9862055-Aged,
pubmed-meshheading:9862055-Antineoplastic Agents,
pubmed-meshheading:9862055-Arrhythmias, Cardiac,
pubmed-meshheading:9862055-Doxorubicin,
pubmed-meshheading:9862055-Drug Administration Schedule,
pubmed-meshheading:9862055-Electrocardiography,
pubmed-meshheading:9862055-Female,
pubmed-meshheading:9862055-Humans,
pubmed-meshheading:9862055-Male,
pubmed-meshheading:9862055-Middle Aged,
pubmed-meshheading:9862055-Piperidines,
pubmed-meshheading:9862055-Torsades de Pointes,
pubmed-meshheading:9862055-Triazines
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|
pubmed:year |
1998
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|
pubmed:articleTitle |
Ventricular arrhythmia and torsade de pointe: dose limiting toxicities of the MDR-modulator S9788 in a phase I trial.
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|
pubmed:affiliation |
University Hospital CHUV, Centre Pluridisciplinaire d'Oncologie, Lausanne, Switzerland.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Clinical Trial, Phase I
|
