Linked Life Data

9861549

Source:http://linkedlifedata.com/resource/pubmed/id/9861549

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-3-22
pubmed:abstractText
The present study examined the effects of opiate receptor antagonism on both the motivation to seek heroin and the reinforcing consequences of heroin administration. Subjects were trained to discriminate between olfactory cues predicting either the delivery of intravenous heroin reinforcement (S+) or saline (S-). Subjects were then tested in the presence of the opiate receptor antagonist, naloxone (0.5, 1.0, or 3.0 mg/kg intraperitoneally). Naloxone had no effect on either S+ or S- trials. However, 24 hr later on the first posttreatment trial, subjects that had received heroin in the presence of naloxone (on the previous trial) now traversed the alley more slowly when presented with the S+. These data suggest that although the motivation to seek heroin was not disrupted by naloxone, the reinforcing consequences of heroin administration were.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1064-1297
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
353-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Naloxone blocks reinforcement but not motivation in an operant runway model of heroin-seeking behavior.
pubmed:affiliation
University of California, Santa Barbara 93106, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't