Linked Life Data

9860095

Source:http://linkedlifedata.com/resource/pubmed/id/9860095

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-2-4
pubmed:abstractText
This study was undertaken to test the effects of a low dose of continuous glucocorticoid infusion on the rate of progression of dentinal caries in molars of young rats. Forty-seven rats were inoculated in the mouth with Streptococcus sobrinus and fed ad libitum a cariogenic diet and 10% sweetened water. After 10 days of caries initiation ten animals were killed to serve as a reference group. In the rest of the animals the cortisone or placebo pellet was implanted subcutaneously in the back of the neck. The daily release of cortisone was 0.42 mg per rat. Sweetened water was changed to pure water, and the diet was the same cariogenic diet. After 6 weeks of medication the areas of dentinal caries were quantified planimetrically. Schiff's staining was used to classify caries. Although cortisone medication slightly increased the number of carious lesions, statistical significance was not reached. However, compared with the placebo group, the rats receiving cortisone medication showed significantly increased dentinal caries progression and severity of lesions. This study suggests that glucocorticoids with a cariogenic diet reduce the intrinsic modulation or response of the odontoblasts to caries attack.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0001-6357
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
276-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Effects of continuous glucocorticoid infusion on the progression of dentinal caries in growing rats.
pubmed:affiliation
Institute of Dentistry, University of Oulu, and University Hospital of Oulu, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't