Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0014644,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0019704,
umls-concept:C0021311,
umls-concept:C0035820,
umls-concept:C0161816,
umls-concept:C0178795,
umls-concept:C0242781,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1257890,
umls-concept:C1521725,
umls-concept:C1521761,
umls-concept:C1521797,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1858460,
umls-concept:C2603343,
umls-concept:C2709248
|
| pubmed:issue |
5
|
| pubmed:dateCreated |
1998-12-31
|
| pubmed:abstractText |
The association of maternal and perinatal factors with mother-infant transmission of HIV-1 was examined in a prospective multicenter cohort of singleton live births to 508 HIV-1-infected women with children of known HIV-1 infection status (91 [18%] HIV-1-infected, 417 [82%] uninfected). From multivariate logistic regression, independent predictors of HIV-1 transmission included maternal CD4 percentage (CD4%) (odds ratio [OR] per 10% increase in CD4% = 0.70; p = .003), ruptured membranes <24 hours (OR = 3.15; p = .02), and maternal bleeding (OR = 2.90; p = .03), whereas maternal zidovudine (ZDV) use was marginally associated (OR = 0.60; p = .08). The associations of maternal urinary cytomegalovirus (CMV) shedding, oropharyngeal Epstein-Barr virus (EBV) shedding, and serology profiles during pregnancy with HIV-1 transmission were examined in the subset of mothers in whom the CMV and EBV measurements were available. Maternal EBV seropositivity, CMV shedding, and CMV seropositivity were 100% (279 of 279), 7% (16 of 229), and 92% (270 of 274), respectively. These rates did not differ between transmitting and nontransmitting mothers. In univariate analyses, maternal EBV shedding was higher among transmitting than nontransmitting mothers (40 of 49 [82%] compared with 154 of 226 [68%]; p = .06) and was independently associated with transmission in multivariate logistic analyses adjusting for CD4%, ruptured membranes, and ZDV use, with an OR of 2.45 (95% confidence interval (CI), 1.03-5.84; p = .04). This permits the conclusion that EBV shedding is associated with maternal-infant HIV-1 transmission, independent of CD4%.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1077-9450
|
| pubmed:author |
pubmed-author:BoyerPP,
pubmed-author:CooperEE,
pubmed-author:GoldfarbJJ,
pubmed-author:HammillHH,
pubmed-author:HodesDD,
pubmed-author:JensonHH,
pubmed-author:KovacsAA,
pubmed-author:LaRussaPP,
pubmed-author:McIntoshKK,
pubmed-author:PeavyHH,
pubmed-author:PittJJ,
pubmed-author:SchluchterMM,
pubmed-author:ShearerWW,
pubmed-author:SperlingRR,
pubmed-author:TuomalaRR
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
462-70
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9859959-Anti-HIV Agents,
pubmed-meshheading:9859959-CD4 Lymphocyte Count,
pubmed-meshheading:9859959-CD4-CD8 Ratio,
pubmed-meshheading:9859959-Cohort Studies,
pubmed-meshheading:9859959-Cytomegalovirus,
pubmed-meshheading:9859959-Female,
pubmed-meshheading:9859959-Gestational Age,
pubmed-meshheading:9859959-HIV Infections,
pubmed-meshheading:9859959-HIV-1,
pubmed-meshheading:9859959-Herpesviridae Infections,
pubmed-meshheading:9859959-Herpesvirus 4, Human,
pubmed-meshheading:9859959-Humans,
pubmed-meshheading:9859959-Infant, Newborn,
pubmed-meshheading:9859959-Infectious Disease Transmission, Vertical,
pubmed-meshheading:9859959-Male,
pubmed-meshheading:9859959-Oropharynx,
pubmed-meshheading:9859959-Pregnancy,
pubmed-meshheading:9859959-Pregnancy Complications, Infectious,
pubmed-meshheading:9859959-Prospective Studies,
pubmed-meshheading:9859959-Risk Factors,
pubmed-meshheading:9859959-Urine,
pubmed-meshheading:9859959-Uterine Hemorrhage,
pubmed-meshheading:9859959-Virus Shedding,
pubmed-meshheading:9859959-Zidovudine
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Maternal and perinatal factors related to maternal-infant transmission of HIV-1 in the P2C2 HIV study: the role of EBV shedding. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV-1 Infection (P2C2 HIV) Study Group.
|
| pubmed:affiliation |
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Multicenter Study
|