Linked Life Data

9858940

Source:http://linkedlifedata.com/resource/pubmed/id/9858940

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5A
pubmed:dateCreated
1998-12-29
pubmed:abstractText
The interaction between sodium 5,6-benzylidene-L-ascorbate (SBA) and dopamine was investigated by three different parameters: radical intensity, prooxidant action and cytotoxic activity. Under alkaline conditions, SBA and dopamine produced doublet and quartet ESR signals, respectively. The addition of increasing concentrations of SBA completely scavenged the dopamine radical and replaced the latter with its own radical. On the other hand, dopamine accelerated the decay of SBA radical. These two compounds stimulated the methionine oxidation in culture medium, but in combination, their stimulation activities were weakened. Both of these two compounds dose-dependently reduced the viable cell number of human promyelocytic leukemics HL-60 cells. When these two compounds were mixed together before adding to HL-60 cells, both of their cytotoxic activities were diminished. The present study demonstrates the interaction between SBA and dopamine, which might modify their biological activities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3565-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Interaction between sodium 5,6-benzylidene-L-ascorbate and dopamine.
pubmed:affiliation
Analysis Center, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
pubmed:publicationType
Journal Article