| pubmed-article:9856983 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9856983 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9856983 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:9856983 | lifeskim:mentions | umls-concept:C0389995 | lld:lifeskim |
| pubmed-article:9856983 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:9856983 | lifeskim:mentions | umls-concept:C0600138 | lld:lifeskim |
| pubmed-article:9856983 | lifeskim:mentions | umls-concept:C0128818 | lld:lifeskim |
| pubmed-article:9856983 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:9856983 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:9856983 | pubmed:issue | 52 | lld:pubmed |
| pubmed-article:9856983 | pubmed:dateCreated | 1999-2-3 | lld:pubmed |
| pubmed-article:9856983 | pubmed:abstractText | Rho-associated kinase (Rho-kinase), which is activated by the small GTPase Rho, phosphorylates moesin at Thr558 in vitro. Here, using a site- and phosphorylation state-specific antibody, we found that the expression of dominant active RhoA in COS7 cells induced moesin phosphorylation and the formation of microvilli-like structures at apical membranes where the Thr558-phosphorylated moesin accumulated, whereas the expression of dominant negative Rho-kinase inhibited both of these processes. The expression of dominant active Rho-kinase also induced moesin phosphorylation. When COS7 cells expressing moesin or moesinT558A (substitution of Thr by Ala) were cultured under serum-depleted conditions, there were few microvilli-like structures, whereas microvilli-like structures remained in the cells expressing moesinT558D (substitution of Thr by Asp). The expression of moesinT558A inhibited the dominant active RhoA-induced formation of microvilli-like structures. These results indicate that Rho-kinase regulates moesin phosphorylation downstream of Rho in vivo and that the phosphorylation of moesin by Rho-kinase plays a crucial role in the formation of microvilli-like structures. | lld:pubmed |
| pubmed-article:9856983 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9856983 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9856983 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9856983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9856983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9856983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9856983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9856983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9856983 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9856983 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9856983 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9856983 | pubmed:author | pubmed-author:FukataYY | lld:pubmed |
| pubmed-article:9856983 | pubmed:author | pubmed-author:KaibuchiKK | lld:pubmed |
| pubmed-article:9856983 | pubmed:author | pubmed-author:OshiroNN | lld:pubmed |
| pubmed-article:9856983 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9856983 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:9856983 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9856983 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9856983 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9856983 | pubmed:pagination | 34663-6 | lld:pubmed |
| pubmed-article:9856983 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9856983 | pubmed:meshHeading | pubmed-meshheading:9856983-... | lld:pubmed |
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| pubmed-article:9856983 | pubmed:meshHeading | pubmed-meshheading:9856983-... | lld:pubmed |
| pubmed-article:9856983 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9856983 | pubmed:articleTitle | Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures. | lld:pubmed |
| pubmed-article:9856983 | pubmed:affiliation | Division of Signal Transduction, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma 630-0101, Japan. | lld:pubmed |
| pubmed-article:9856983 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9856983 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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