Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1998-12-23
|
| pubmed:abstractText |
With the use of a specific high-performance liquid chromatography (HPLC) method and a bioassay which determines trypanocidal activity, concentrations of melarsoprol were assessed in plasma, urine and cerebrospinal fluid (CSF) from 8 patients with late-stage Trypanosoma gambiense sleeping sickness. The aim was to unravel to what extent the bioassay codetermines biologically active metabolites of melarsoprol.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1360-2276
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
913-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9855405-Adolescent,
pubmed-meshheading:9855405-Adult,
pubmed-meshheading:9855405-Animals,
pubmed-meshheading:9855405-Biological Assay,
pubmed-meshheading:9855405-Child,
pubmed-meshheading:9855405-Chromatography, High Pressure Liquid,
pubmed-meshheading:9855405-Female,
pubmed-meshheading:9855405-Humans,
pubmed-meshheading:9855405-Male,
pubmed-meshheading:9855405-Melarsoprol,
pubmed-meshheading:9855405-Trypanocidal Agents,
pubmed-meshheading:9855405-Trypanosoma brucei gambiense,
pubmed-meshheading:9855405-Trypanosomiasis, African
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Discrepancy in plasma melarsoprol concentrations between HPLC and bioassay methods in patients with T. gambiense sleeping sickness indicates that melarsoprol is metabolized.
|
| pubmed:affiliation |
Division of Clinical Pharmacology, Karolinska Institute, Huddinge, Sweden. Ulf.Bronner@impi.ki.se
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|