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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-3-12
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pubmed:abstractText |
Following treatment with interleukin-10 (IL-10), basal corticotrophin releasing factor (CRF) levels from rat hypothalamic median eminence (ME) were found to be increased. Our data show: (1) the specificity of stimulation of CRF through the use of recombinant IL-10 and its blockage by monoclonal anti-IL-10 antibody; (2) the requirement of NO in this process through the use of N(omega)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor; (3) the blockage of IL-10 stimulated NO production by anti-IL-10; and, (4) the presence of IL-10 transcripts in hypothalamic poly A+ mRNA. These results provide the first evidence of IL-10 acting in the ME to influence CRF levels and further support our earlier findings of a potential for IL-10 in the hypothalamic-pituitary axis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Corticotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester,
http://linkedlifedata.com/resource/pubmed/chemical/NOS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Nos1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
256
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
167-70
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9855366-Animals,
pubmed-meshheading:9855366-Antibodies, Monoclonal,
pubmed-meshheading:9855366-Blotting, Southern,
pubmed-meshheading:9855366-Corticotropin-Releasing Hormone,
pubmed-meshheading:9855366-Dose-Response Relationship, Drug,
pubmed-meshheading:9855366-Humans,
pubmed-meshheading:9855366-Interleukin-10,
pubmed-meshheading:9855366-Leukocytes,
pubmed-meshheading:9855366-Male,
pubmed-meshheading:9855366-Median Eminence,
pubmed-meshheading:9855366-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:9855366-Nitric Oxide,
pubmed-meshheading:9855366-Nitric Oxide Synthase,
pubmed-meshheading:9855366-Nitric Oxide Synthase Type I,
pubmed-meshheading:9855366-Pituitary Gland,
pubmed-meshheading:9855366-RNA, Messenger,
pubmed-meshheading:9855366-Rats,
pubmed-meshheading:9855366-Rats, Wistar,
pubmed-meshheading:9855366-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:9855366-Specific Pathogen-Free Organisms
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pubmed:year |
1998
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pubmed:articleTitle |
Interleukin-10 stimulation of corticotrophin releasing factor median eminence in rats: evidence for dependence upon nitric oxide production.
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pubmed:affiliation |
Neuroscience Research Institute, SUNY/College at Old Westbury, NY 11568, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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