Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-3-22
pubmed:abstractText
We have reported previously that thyroid hormone activates the circulating and tissue renin-angiotensin systems without involving the sympathetic nervous system, which contributes to cardiac hypertrophy in hyperthyroidism. This study examined whether the circulating or tissue renin-angiotensin system plays the principal role in hyperthyroidism-induced cardiac hypertrophy. The circulating renin-angiotensin system in Sprague-Dawley rats was fixed by chronic angiotensin II infusion (40 ng/min, 28 days) via mini-osmotic pumps. Daily i.p. injection of thyroxine (0.1 mg/kg per day, 28 days) was used to mimic hyperthyroidism. Serum free tri-iodothyronine, plasma renin activity, plasma angiotensin II, cardiac renin and cardiac angiotensin II were measured with RIAs. The cardiac expression of renin mRNA was evaluated by semiquantitative reverse transcriptase-polymerase chain reaction. Plasma renin activity and plasma angiotensin II were kept constant in the angiotensin II and angiotensin II+thyroxine groups (0.12+/-0.03 and 0.15+/-0.03 microgram/h per liter, 126+/-5 and 130+/-5 ng/l respectively) (means+/-s.e.m.). Despite stabilization of the circulating renin-angiotensin system, thyroid hormone induced cardiac hypertrophy (5.0+/-0.5 vs 3.5+/-0.1 mg/g) in conjunction with the increases in cardiac expression of renin mRNA, cardiac renin and cardiac angiotensin II (74+/-2 vs 48+/-2%, 6.5+/-0.8 vs 3.8+/-0.4 ng/h per g, 231+/-30 vs 149+/-2 pg/g respectively). These results indicate that the local renin-angiotensin system plays the primary role in the development of hyperthyroidism-induced cardiac hypertrophy.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-1108062, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-1415533, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-1824620, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-2154700, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-2189307, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-2294136, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-2328703, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-2537405, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-2987855, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-3185726, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-3287330, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-3359576, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-3529982, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-3893995, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-4401157, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-6318542, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-6321055, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-7506697, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-7522404, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-7581987, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-7843775, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-7961740, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-8304477, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-8342523, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-8373515, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-8386920, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-8443912, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-8613220, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-9124327, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-9225731, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-9277473, http://linkedlifedata.com/resource/pubmed/commentcorrection/9854175-9486151
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-0795
pubmed:author
pubmed:issnType
Print
pubmed:volume
160
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-7
pubmed:dateRevised
2010-8-13
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Local renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy.
pubmed:affiliation
Department of Internal Medicine, School of Medicine, Keio University, 160-8582, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't