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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1999-2-11
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pubmed:abstractText |
Conventional peritoneal dialysis fluids (PDF) have been shown to compromise the function of both leukocytes and human peritoneal mesothelial cells (HPMC). Various in vitro studies have identified the low initial pH in combination with high lactate content, as well as the hyperosmolality and high glucose concentration present in currently used solutions as the primary determinants of their bioincompatibility. Bicarbonate buffered PDF (at neutral pH) display improved in vitro biocompatibility as compared to conventional, lactate buffered PDF. However, little information is currently available regarding the potential impact of PDF on the function of human peritoneal fibroblasts (HPFB), the major cell population present in peritoneal interstitium.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bicarbonates,
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Buffers,
http://linkedlifedata.com/resource/pubmed/chemical/Dialysis Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0085-2538
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2184-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9853285-Bicarbonates,
pubmed-meshheading:9853285-Biocompatible Materials,
pubmed-meshheading:9853285-Buffers,
pubmed-meshheading:9853285-Cells, Cultured,
pubmed-meshheading:9853285-Dialysis Solutions,
pubmed-meshheading:9853285-Dose-Response Relationship, Drug,
pubmed-meshheading:9853285-Epithelial Cells,
pubmed-meshheading:9853285-Fibroblasts,
pubmed-meshheading:9853285-Humans,
pubmed-meshheading:9853285-Interleukin-6,
pubmed-meshheading:9853285-Peritoneal Cavity,
pubmed-meshheading:9853285-Peritoneal Dialysis,
pubmed-meshheading:9853285-Time Factors
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pubmed:year |
1998
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pubmed:articleTitle |
Biocompatibility and buffers: effect of bicarbonate-buffered peritoneal dialysis fluids on peritoneal cell function.
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pubmed:affiliation |
Department of Nephrology and Intensive-Care Medicine, Universitätsklinikum Charité, Medizinische Fakultät, Humboldt-Universität zu Berlin, Germany. achim.joerres@charite.de
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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