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rdf:type |
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lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0009015,
umls-concept:C0017262,
umls-concept:C0033684,
umls-concept:C0185117,
umls-concept:C0475264,
umls-concept:C0936012,
umls-concept:C1415504,
umls-concept:C1415546,
umls-concept:C1825475,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
1999-1-13
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pubmed:databankReference |
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pubmed:abstractText |
Huntington disease (HD) is an inherited neurodegenerative disorder which is associated with CAG expansion in the coding region of the gene for huntingtin protein. Recently, a huntingtin interacting protein, HIP1, was isolated by the yeast two-hybrid system. Here we report the isolation of a cDNA clone for HIP1R (huntingtin interacting protein-1 related), which encodes a predicted protein product sharing a striking homology with HIP1. RT-PCR analysis showed that the messenger RNA was ubiquitously expressed in various human tissues. Based on PCR-assisted analysis of a radiation hybrid panel and fluorescence in situ hybridization, HIP1R was localized to the q24 region of chromosome 12.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1434-5161
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
268-71
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9852681-Amino Acid Sequence,
pubmed-meshheading:9852681-Carrier Proteins,
pubmed-meshheading:9852681-Chromosome Mapping,
pubmed-meshheading:9852681-Chromosomes, Human, Pair 12,
pubmed-meshheading:9852681-Cloning, Molecular,
pubmed-meshheading:9852681-Cytoskeletal Proteins,
pubmed-meshheading:9852681-DNA-Binding Proteins,
pubmed-meshheading:9852681-Fungal Proteins,
pubmed-meshheading:9852681-Gene Expression,
pubmed-meshheading:9852681-Humans,
pubmed-meshheading:9852681-Huntington Disease,
pubmed-meshheading:9852681-In Situ Hybridization, Fluorescence,
pubmed-meshheading:9852681-Molecular Sequence Data,
pubmed-meshheading:9852681-Neuroblastoma,
pubmed-meshheading:9852681-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:9852681-Sequence Alignment,
pubmed-meshheading:9852681-Tumor Cells, Cultured,
pubmed-meshheading:9852681-Vesicular Transport Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1).
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pubmed:affiliation |
Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan.
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pubmed:publicationType |
Journal Article
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