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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-4
|
| pubmed:dateCreated |
1999-2-4
|
| pubmed:databankReference | |
| pubmed:abstractText |
Bovine respiratory syncytial virus (BRSV) strains are tentatively divided in subgroups A, AB and B, based on antigenic differences of the G protein. A Dutch BRSV strain (Waiboerhoeve: WBH), could not be assigned to one of the subgroups, because the strain did not react with any monoclonal antibody against the G protein. We describe here that the WBH strain has accumulated critical mutations in subgroup-specific domains of the G protein gene, which also occur but then independently in G protein genes of BRSV subgroup A or B strains. Although the comparison of nucleotide residues 256-792 of the G gene of the WBH strain with those of subgroup A and B strains showed that the G gene of the WBH strain is different from that of BRSV subgroup A and B strains, the sequence divergence was not more than observed within the G genes of human respiratory syncytial virus subgroup A or B strains. The WBH strain did not induce severe disease after experimental infection of calves, and induced partial protection against a heterologous challenge. Despite the dissimilarity of the conserved central regions of the G protein of the WBH strain and that of the challenge strain, a secondary antibody response against this region was induced in WBH-infected calves after challenge. We conclude that complete BRSV virus can partially protect against a BRSV infection with a strain that contains an antigenic dissimilar G protein.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0378-1135
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
63
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
159-75
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9850996-Amino Acid Sequence,
pubmed-meshheading:9850996-Animals,
pubmed-meshheading:9850996-Antibodies, Viral,
pubmed-meshheading:9850996-Antibody Formation,
pubmed-meshheading:9850996-Antigens, Viral,
pubmed-meshheading:9850996-Base Sequence,
pubmed-meshheading:9850996-Cattle,
pubmed-meshheading:9850996-Cattle Diseases,
pubmed-meshheading:9850996-Cercopithecus aethiops,
pubmed-meshheading:9850996-Evolution, Molecular,
pubmed-meshheading:9850996-Humans,
pubmed-meshheading:9850996-Molecular Sequence Data,
pubmed-meshheading:9850996-Mutation,
pubmed-meshheading:9850996-Netherlands,
pubmed-meshheading:9850996-Phylogeny,
pubmed-meshheading:9850996-Respiratory Syncytial Virus, Bovine,
pubmed-meshheading:9850996-Respiratory Syncytial Virus, Human,
pubmed-meshheading:9850996-Respiratory Syncytial Virus Infections,
pubmed-meshheading:9850996-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:9850996-Sequence Alignment,
pubmed-meshheading:9850996-Sequence Homology, Amino Acid,
pubmed-meshheading:9850996-Sequence Homology, Nucleic Acid,
pubmed-meshheading:9850996-Sheep,
pubmed-meshheading:9850996-Sheep Diseases,
pubmed-meshheading:9850996-Vero Cells,
pubmed-meshheading:9850996-Viral Envelope Proteins
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
A bovine respiratory syncytial virus strain with mutations in subgroup-specific antigenic domains of the G protein induces partial heterologous protection in cattle.
|
| pubmed:affiliation |
Department of Mammalian Virology, DLO-Institute for Animal Science and Health (ID-DLO), Lelystad, The Netherlands. r.s.schrijver@id.dlo.nl
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|