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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1999-1-22
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pubmed:abstractText |
In order to evaluate if a patented soft gelatine capsule could improve the bioavailability of silybin (CAS 22888-70-6) in comparison to a hard shell capsule, an open, single dose, two-way, balanced cross-over study, was performed. The study was conducted on 12 healthy subjects (6 M and 6 F). 80 mg of silybin in a 1:2 complex with phosphatidylcholine was administered. Blood was sampled from the subjects in two occasions at the following times after drug administrations: 0 (sample before dosing), 1, 2, 3, 4, 6 and 8 h. The pharmacokinetic parameters calculated from the results of the plasma analyses demonstrated that the mean values of both Cmax and AUC0-1 were increased when the patented soft gelatine capsule formulations were administered (i.e. Cmax more than 3-fold and AUC0-1 more than 2-fold).
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0004-4172
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1104-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9850434-Adolescent,
pubmed-meshheading:9850434-Adult,
pubmed-meshheading:9850434-Antioxidants,
pubmed-meshheading:9850434-Area Under Curve,
pubmed-meshheading:9850434-Biological Availability,
pubmed-meshheading:9850434-Capsules,
pubmed-meshheading:9850434-Cross-Over Studies,
pubmed-meshheading:9850434-Female,
pubmed-meshheading:9850434-Gels,
pubmed-meshheading:9850434-Humans,
pubmed-meshheading:9850434-Intestinal Absorption,
pubmed-meshheading:9850434-Male,
pubmed-meshheading:9850434-Middle Aged,
pubmed-meshheading:9850434-Silymarin
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pubmed:year |
1998
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pubmed:articleTitle |
Softgel capsule technology as an enhancer device for the absorption of natural principles in humans. A bioavailability cross-over randomised study on silybin.
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pubmed:affiliation |
EUCLIDEA S.r.I., Frascati, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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