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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11 Pt 1
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pubmed:dateCreated |
1999-2-16
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pubmed:abstractText |
Crevicular fluid pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is predictive for future alveolar bone loss in experimental periodontitis in dogs. The present study sought to relate ICTP to a panel of subgingival species in subjects exhibiting various clinical presentations such as health (n=7), gingivitis (n=8) and periodontitis (n=21). 28 subgingival plaque and GCF samples were taken from mesiobuccal sites in each of 36 subjects. The presence and levels of 40 subgingival taxa were determined in plaque samples using whole genomic DNA probes and checkerboard DNA-DNA hybridization. GCF ICTP levels were quantified using radioimmunoassay (RIA). Clinical assessments made at the same sites included: BOP, gingival redness, plaque, pocket depth, and attachment level. Differences among ICTP levels in the 3 subject groups were sought using the Kruskal-Wallis test. Relationships between ICTP levels and clinical parameters as well as subgingival species were determined by regression analysis. The results demonstrated significant differences among disease categories for GCF ICTP levels for healthy (1.1+0.6 pg/site (mean+/-SEM)) gingivitis (14.8+/-6.6 pg/site) and periodontitis subjects (30.3+5.7 pg/site) (p= 0.0017). ICTP levels related modestly to several clinical parameters. Regression analysis indicated that ICTP levels correlated strongly with mean subject levels of several periodontal pathogens including B. forsythus, P. gingivalis, P. intermedia, P. nigrescens and T. denticola (p<0.01). The data indicate that there is a positive relationship between the putative bone resorptive marker ICTP and periodontal pathogens.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-1315388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-1831843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-2005225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-2524576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-6575980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-6583243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-7817828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-8034776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-8118750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-8199535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-8355985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-8442431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-8472358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-8550866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-8613557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-8854049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-9087964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-9118264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-9134120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-9150045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-9178112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-9297576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-9495612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-9655016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9846794-9673164
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0303-6979
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
865-71
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9846794-Adult,
pubmed-meshheading:9846794-Aged,
pubmed-meshheading:9846794-Biological Markers,
pubmed-meshheading:9846794-Collagen,
pubmed-meshheading:9846794-Collagen Type I,
pubmed-meshheading:9846794-Dental Plaque,
pubmed-meshheading:9846794-Discriminant Analysis,
pubmed-meshheading:9846794-Female,
pubmed-meshheading:9846794-Gingival Crevicular Fluid,
pubmed-meshheading:9846794-Gingivitis,
pubmed-meshheading:9846794-Humans,
pubmed-meshheading:9846794-Male,
pubmed-meshheading:9846794-Middle Aged,
pubmed-meshheading:9846794-Peptides,
pubmed-meshheading:9846794-Periodontitis,
pubmed-meshheading:9846794-Prognosis,
pubmed-meshheading:9846794-Regression Analysis,
pubmed-meshheading:9846794-Statistics, Nonparametric
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pubmed:year |
1998
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pubmed:articleTitle |
Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis.
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pubmed:affiliation |
Department of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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