Linked Life Data

9846053

Source:http://linkedlifedata.com/resource/pubmed/id/9846053

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-1-12
pubmed:abstractText
Diabetes mellitus (DM) often causes neural dysfunctions, including visual disorders. To investigate the effect of hyperglycemia on the visual system, we studied the metabolism of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter that has an important role in visual functions. We determined the GABA content and activities of glutamate decarboxylase (GAD) and GABA transaminase (GABA-T) in the retina and superior colliculus (SC) in streptozotocin (STZ)-induced DM rats. The GABA content and activities of GAD and GABA-T were decreased in the retinas of STZ-treated rats. The GABA content and GAD activity were reduced in the SC of STZ-treated rats, whereas GABA-T activity showed no marked change. This GABA reduction in the diabetes may be correlated with visual dysfunctions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0023-2513
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-8
pubmed:dateRevised
2008-4-8
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Alteration of the GABAergic neuronal system of the retina and superior colliculus in streptozotocin-induced diabetic rat.
pubmed:affiliation
Department of Physiology, Kobe University School of Medicine.
pubmed:publicationType
Journal Article, Comparative Study