Linked Life Data

9845777

Source:http://linkedlifedata.com/resource/pubmed/id/9845777

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-2-10
pubmed:abstractText
The solubility and stability of the chemically unstable drug tetrazepam which has poor water solubility have been studied in bile salts-phosphatidylcholine-mixed micelles (BS-PC-MM). The solubilization potential of BS-PC-MM was much higher than that of BS alone. The use of soya-PC (SPC) instead of egg-PC (EPC) increased the solubilization capacity of MM. The results of the stability studies indicated first order degradation kinetics in most cases under aerobic conditions. An Arrhenius plot could be constructed in a temperature range from 30 to 60 degrees C in sodium deoxycholate-SPC-MM (SDC-SPC-MM) as well as in phosphate buffer at pH 7.4. Sodium glycocholate-SPC-MM (SGC-SPC-MM) interfered with the degradation kinetics and displayed better stabilizing effects under both aerobic and anaerobic conditions. The addition of ascorbic acid (AA) protected tetrazepam to some extent, whereas Na2SO3 or Na2S2O5 were incompatible with it. Formulating tetrazepam in SGC-SPC-MM containing 0.1% AA resulted in a shelf stability of more than 1 year under anaerobic conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0928-0987
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-55
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Solubility and stability of tetrazepam in mixed micelles.
pubmed:affiliation
Christian-Albrechts-University, Department of Pharmaceutics and Biopharmaceutics, Gutenbergstrasse 76, 24118, Kiel, Germany.
pubmed:publicationType
Journal Article