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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1999-1-6
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pubmed:abstractText |
Atypical glandular cells of undetermined significance (AGUS) is a diagnostic category of the Bethesda system encompassing glandular-type cells that show either endometrial or endocervical differentiation and display greater atypia than expected for a reactive process but do not meet the criteria for invasive adenocarcinoma. We investigated AGUS in a follow-up study of cervical-endocervical smears with either histology or repeat cytology follow-up. From the cytology files at Northwestern Memorial Hospital over a 4-year period, 136 cervical-endocervical smears were diagnosed with AGUS, which were further subdivided into atypical glandular cells, unqualified (AGC-U); atypical glandular cells, favor reactive (AGC-FR); or atypical glandular cells, favor neoplasia (AGC-FN). Of 96 cases with either histologic or cytologic (cervical-endocervical smear) follow-up, 39 cases of AGC-U had a variety of diagnoses on follow-up, with mostly benign entities in 72% and squamous intraepithelial lesions in 28%. Follow-up of the 36 cases of AGC-FR also demonstrated mostly benign entities (82%) and five cases of squamous intraepithelial lesions. The largest number of premalignant and malignant diagnoses (48%) was found during follow-up of patients with an initial diagnosis of AGC-FN, including the only two cases of adenocarcinoma in situ in our study. In conclusion, our study confirms that AGUS encompasses a wide spectrum of diagnoses, most of which prove to be benign. Subclassification of these cases into "favor reactive" and "favor neoplasia" was found to be helpful in predicting the follow-up status of these patients. However, the small but distinctive percentage of preneoplastic and neoplastic diagnoses seen on follow-up warrant further diagnostic procedures and/or close monitoring in patients with this diagnosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1092-9134
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
312-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9845755-Adenocarcinoma,
pubmed-meshheading:9845755-Cervix Uteri,
pubmed-meshheading:9845755-Conization,
pubmed-meshheading:9845755-Endometriosis,
pubmed-meshheading:9845755-Endometrium,
pubmed-meshheading:9845755-Exocrine Glands,
pubmed-meshheading:9845755-Female,
pubmed-meshheading:9845755-Follow-Up Studies,
pubmed-meshheading:9845755-Histocytochemistry,
pubmed-meshheading:9845755-Humans,
pubmed-meshheading:9845755-Laboratories,
pubmed-meshheading:9845755-Precancerous Conditions,
pubmed-meshheading:9845755-Reproducibility of Results,
pubmed-meshheading:9845755-Terminology as Topic,
pubmed-meshheading:9845755-Uterine Cervical Diseases,
pubmed-meshheading:9845755-Vaginal Smears
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pubmed:year |
1998
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pubmed:articleTitle |
Follow-up of atypical glandular cells in cervical-endocervical smears.
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pubmed:affiliation |
Departments of Pathology, Cytopathology, and Obstetrics & Gynecology, Northwestern University Medical School, Chicago, IL, USA.
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pubmed:publicationType |
Journal Article
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