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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1999-2-5
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pubmed:abstractText |
Very late antigen-4 (VLA-4)/vascular cell adhesion molecule-1 (VCAM-1) are a pair of adhesion molecules mediating cell-cell interaction. The binding activity of each depends on its surface expression, yet integrin activity can also be modulated through inside-out signaling. However, the specific intracellular molecules involved in modulating integrin VLA-4 activation via inside-out signaling or in regulating VCAM-1 expression are poorly understood. We show here that constitutive coexpression of cyclin C and c-Myc in hematopoietic BAF-B03 cells induces homotypic cell adhesion, which results from enhanced VLA-4 ligand-binding activity and induced expression of VCAM-1. Furthermore, regulation of cell adhesion appears to be a feature unique to cyclin C, but not other G1 cyclins, E and D3, and its regulatory function is independent of CDK8 kinase activity. Our results provide a novel role for cyclin C and c-Myc in the regulation of cell adhesion through distinct mechanisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Blocking,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD29,
http://linkedlifedata.com/resource/pubmed/chemical/CCNC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CDK8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ccnc protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin C,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha4,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha4beta1,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lymphocyte Homing,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Very Late Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4700-11
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9845536-Animals,
pubmed-meshheading:9845536-Antibodies, Blocking,
pubmed-meshheading:9845536-Antigens, CD,
pubmed-meshheading:9845536-Antigens, CD29,
pubmed-meshheading:9845536-Cell Adhesion,
pubmed-meshheading:9845536-Cell Adhesion Molecules,
pubmed-meshheading:9845536-Cell Cycle,
pubmed-meshheading:9845536-Cell Division,
pubmed-meshheading:9845536-Cell Line,
pubmed-meshheading:9845536-Cyclin C,
pubmed-meshheading:9845536-Cyclin-Dependent Kinase 8,
pubmed-meshheading:9845536-Cyclin-Dependent Kinases,
pubmed-meshheading:9845536-Cyclins,
pubmed-meshheading:9845536-Enzyme Activation,
pubmed-meshheading:9845536-Hematopoietic Stem Cells,
pubmed-meshheading:9845536-Humans,
pubmed-meshheading:9845536-Integrin alpha4,
pubmed-meshheading:9845536-Integrin alpha4beta1,
pubmed-meshheading:9845536-Integrins,
pubmed-meshheading:9845536-Mice,
pubmed-meshheading:9845536-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9845536-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:9845536-Receptors, Lymphocyte Homing,
pubmed-meshheading:9845536-Receptors, Very Late Antigen,
pubmed-meshheading:9845536-Transfection,
pubmed-meshheading:9845536-Vascular Cell Adhesion Molecule-1
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pubmed:year |
1998
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pubmed:articleTitle |
Functional cooperation of cyclin C and c-Myc in mediating homotypic cell adhesion via very late antigen-4 activation and vascular cell adhesion molecule-1 induction.
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pubmed:affiliation |
Department of Biochemistry and of Laboratory Medicine, Kobe University, School of Medicine, Kobe, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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