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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1999-2-5
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pubmed:abstractText |
We have previously shown that infection of CD4(+) T lymphocytes with the T-lymphotropic human herpesvirus 7 (HHV-7) downregulates surface CD4, which represents the high-affinity receptor for HHV-7. In this study, we report that HHV-7 infection also causes a progressive loss of the surface CXC-chemokine receptor 4 (CXCR4) in CD4(+) T cells, accompanied by a reduced intracellular Ca2+ flux and chemotaxis in response to stromal cell-derived factor-1 (SDF-1), the specific CXCR4 ligand. Moreover, CXCR4 is downregulated from the surface of HHV-7-infected T cells independently of CD4. Because intracellular CXCR4 antigen and mRNA levels are unaffected in productively HHV-7-infected cells, the downregulation of CXCR4 apparently does not involve a transcritional block. Since CXCR4 functions in association with CD4 to permit entry of several human immunodeficiency virus (HIV) isolates, the potential of HHV-7 to persistently downregulate the surface expression of CXCR4 may provide novel strategies for limiting HIV infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/CXCL12 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL12,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4521-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9845516-Antigens, CD4,
pubmed-meshheading:9845516-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9845516-Calcium,
pubmed-meshheading:9845516-Cell Line,
pubmed-meshheading:9845516-Cells, Cultured,
pubmed-meshheading:9845516-Chemokine CXCL12,
pubmed-meshheading:9845516-Chemokines, CXC,
pubmed-meshheading:9845516-Chemotaxis,
pubmed-meshheading:9845516-Down-Regulation,
pubmed-meshheading:9845516-Flow Cytometry,
pubmed-meshheading:9845516-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:9845516-HIV Infections,
pubmed-meshheading:9845516-HIV-1,
pubmed-meshheading:9845516-Herpesviridae Infections,
pubmed-meshheading:9845516-Herpesvirus 7, Human,
pubmed-meshheading:9845516-Humans,
pubmed-meshheading:9845516-Intracellular Fluid,
pubmed-meshheading:9845516-RNA, Messenger,
pubmed-meshheading:9845516-Receptors, CXCR4
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pubmed:year |
1998
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pubmed:articleTitle |
Progressive and persistent downregulation of surface CXCR4 in CD4(+) T cells infected with human herpesvirus 7.
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pubmed:affiliation |
Institute of Human Virology, University of Maryland, Baltimore, MD; and the Human Anatomy Section, Department of Morphology and Embriology, University of Ferrara, Ferrara, Italy. secchier@umbi.umd.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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