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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1998-12-10
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pubmed:abstractText |
The t(9;11)(p22;q23) is the most common chromosomal translocation in topoisomerase II inhibitor therapy-related acute myeloid leukemia (tAML). This translocation fuses the MLL and AF9 proto-oncogenes producing a novel chimeric protein. In order to gain insight into the mechanism generating the t(9;11) and to clarify the role topoisomerase II inhibition may play in that mechanism we have cloned and sequenced the breakpoints from four tAML patients with the t(9;11). This sequence analysis identifies topoisomerase II consensus binding sequences near or at the chromosome 11 and chromosome 9 breakpoints in all four patients. One patient also had the consensus binding sequence for the TRANSLIN DNA-binding protein at the 9p22 and 11q23 breakpoints. Our results further support a direct role for topoisomerase II in the genesis of these tAML translocations.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0887-6924
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1895-902
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9844920-Acute Disease,
pubmed-meshheading:9844920-Adolescent,
pubmed-meshheading:9844920-Amino Acid Sequence,
pubmed-meshheading:9844920-Base Sequence,
pubmed-meshheading:9844920-Child,
pubmed-meshheading:9844920-Child, Preschool,
pubmed-meshheading:9844920-Chromosomes, Human, Pair 11,
pubmed-meshheading:9844920-Chromosomes, Human, Pair 9,
pubmed-meshheading:9844920-Cloning, Molecular,
pubmed-meshheading:9844920-DNA-Binding Proteins,
pubmed-meshheading:9844920-Female,
pubmed-meshheading:9844920-Humans,
pubmed-meshheading:9844920-Leukemia, Myeloid,
pubmed-meshheading:9844920-Male,
pubmed-meshheading:9844920-Molecular Sequence Data,
pubmed-meshheading:9844920-Myeloid-Lymphoid Leukemia Protein,
pubmed-meshheading:9844920-Neoplasm Proteins,
pubmed-meshheading:9844920-Neoplasms, Second Primary,
pubmed-meshheading:9844920-Oncogene Proteins, Fusion,
pubmed-meshheading:9844920-Polymerase Chain Reaction,
pubmed-meshheading:9844920-Proto-Oncogenes,
pubmed-meshheading:9844920-Sensitivity and Specificity,
pubmed-meshheading:9844920-Sequence Analysis, DNA,
pubmed-meshheading:9844920-Topoisomerase II Inhibitors,
pubmed-meshheading:9844920-Transcription Factors,
pubmed-meshheading:9844920-Translocation, Genetic
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pubmed:year |
1998
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pubmed:articleTitle |
Cloning and sequence analysis of four t(9;11) therapy-related leukemia breakpoints.
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pubmed:affiliation |
Department of Pediatrics, Northwestern University, Chicago, IL, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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