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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
1999-1-14
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pubmed:abstractText |
The observation of high frequencies of certain inherited disorders in the population of Saguenay-Lac Saint Jean can be explained in terms of the variance and the correlation of effective family size (EFS) from one generation to the next. We have shown this effect by using the branching process approach with real demographic data. When variance of EFS is included in the model, despite its profound effect on mutant allele frequency, any mutant introduced in the population never reaches the known carrier frequencies (between 0.035 and 0.05). It is only when the EFS correlation between generations is introduced into the model that we can explain the rise of the mutant alleles. This correlation is described by a c parameter that reflects the dependency of children's EFS on their parents' EFS. The c parameter can be considered to reflect social transmission of demographic behavior. We show that such social transmission dramatically reduces the effective population size. This could explain particular distributions in allele frequencies and unusually high frequency of certain inherited disorders in some human populations.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-1937468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-1999446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-2368806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-274730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-4450115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-5120561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-5473413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-5922522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-7689910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-7717408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-7719342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-7825575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-8257082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-8533779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-8673290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-8981963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-9057345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-9326343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844029-9671802
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15140-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1998
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pubmed:articleTitle |
Social transmission of reproductive behavior increases frequency of inherited disorders in a young-expanding population.
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pubmed:affiliation |
Laboratoire Evolution et Systématique, Université Paris-Sud, 91405 Orsay, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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