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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
1999-1-14
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pubmed:abstractText |
The brain serotonin (5-hydroxytryptamine; 5-HT) system is a powerful modulator of emotional processes and a target of medications used in the treatment of psychiatric disorders. To evaluate the contribution of serotonin 5-HT1A receptors to the regulation of these processes, we have used gene-targeting technology to generate 5-HT1A receptor-mutant mice. These animals lack functional 5-HT1A receptors as indicated by receptor autoradiography and by resistance to the hypothermic effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Homozygous mutants display a consistent pattern of responses indicative of elevated anxiety levels in open-field, elevated-zero maze, and novel-object assays. Moreover, they exhibit antidepressant-like responses in a tail-suspension assay. These results indicate that the targeted disruption of the 5-HT1A receptor gene leads to heritable perturbations in the serotonergic regulation of emotional state. 5-HT1A receptor-null mutant mice have potential as a model for investigating mechanisms through which serotonergic systems modulate affective state and mediate the actions of psychiatric drugs.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-1531498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-1663620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-2467224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-2869435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-2894041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-3110823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-3156965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-3161115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-3194019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-3323264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-3505364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-3923523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-7590232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-7698163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-7838922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-7862931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-7870996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-7913324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-7938165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-7940983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-7972418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-8221912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-8539333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-8566121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-8724453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-8728533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-8764667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-8873352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-8972549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-9300624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9844013-9860934
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15049-54
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
pubmed-meshheading:9844013-Animals,
pubmed-meshheading:9844013-Anxiety,
pubmed-meshheading:9844013-Brain,
pubmed-meshheading:9844013-Depression,
pubmed-meshheading:9844013-Gene Targeting,
pubmed-meshheading:9844013-Male,
pubmed-meshheading:9844013-Mice,
pubmed-meshheading:9844013-Mice, Inbred C57BL,
pubmed-meshheading:9844013-Mutation,
pubmed-meshheading:9844013-Receptors, Serotonin
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pubmed:year |
1998
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pubmed:articleTitle |
Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice.
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pubmed:affiliation |
Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143-0984, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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