Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
25
pubmed:dateCreated
1999-1-14
pubmed:abstractText
Our preliminary family studies have suggested that some female first-degree relatives of women with polycystic ovary syndrome (PCOS) have hyperandrogenemia per se. It was our hypothesis that this may be a genetic trait and thus could represent a phenotype suitable for linkage analysis. To investigate this hypothesis, we examined 115 sisters of 80 probands with PCOS from unrelated families. PCOS was diagnosed by the combination of elevated serum androgen levels and </=6 menses per year with the exclusion of secondary causes. The sisters were compared with 70 healthy age- and weight-comparable control women with regular menses, no clinical evidence of hyperandrogenemia, and normal glucose tolerance. Twenty-two percent of the sisters fulfilled diagnostic criteria for PCOS. In addition, 24% of the sisters had hyperandrogenemia and regular menstrual cycles. Circulating testosterone (T) and nonsex hormone-binding globulin-bound testosterone (uT) levels in both of these groups of sisters were significantly increased compared with unaffected sisters and control women (P < 0.0001 for both T and uT). Probands, sisters with PCOS, and hyperandrogenemic sisters had elevated serum luteinizing hormone levels compared with control women. We conclude that there is familial aggregation of hyperandrogenemia (with or without oligomenorrhea) in PCOS kindreds. In affected sisters, only one-half have oligomenorrhea and hyperandrogenemia characteristic of PCOS, whereas the remaining one-half have hyperandrogenemia per se. This familial aggregation of hyperandrogenemia in PCOS kindreds suggests that it is a genetic trait. We propose that hyperandrogenemia be used to assign affected status in linkage studies designed to identify PCOS genes.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-1607066, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-2777131, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-2867389, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-2895373, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-3076848, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-3089520, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-3808511, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-4448070, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-4729055, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-4823918, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-509743, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-7258262, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-7531655, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-7621565, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-7671850, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-7962276, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-8053879, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-8091226, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-8334753, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-848488, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-8522051, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-8687515, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-8784087, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-8941059, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-9408743, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-9455828, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-9745406, http://linkedlifedata.com/resource/pubmed/commentcorrection/9843997-9769710
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14956-60
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome.
pubmed:affiliation
Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't