|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0007634,
umls-concept:C0010709,
umls-concept:C0014609,
umls-concept:C0017262,
umls-concept:C0022646,
umls-concept:C0022677,
umls-concept:C0185117,
umls-concept:C0205615,
umls-concept:C1420634,
umls-concept:C2911684
|
|
pubmed:issue |
6 Pt 2
|
|
pubmed:dateCreated |
1999-2-1
|
|
pubmed:abstractText |
The cDNA coding for the transcriptional repressor protein Kid-1 was cloned in a screen for zinc finger proteins, which are regulated during renal development and after renal ischemia. Kid-1 mRNA levels increase in the course of postnatal renal development and decrease after acute renal injury caused by ischemia or administration of folic acid. We have raised a monoclonal anti-Kid-1 antibody and demonstrate that the Kid-1 protein is strongly expressed in the proximal tubule of the adult rat kidney. During nephron development, the Kid-1 protein appears after the S-shaped body stage concomitantly with the brush-border enzyme alkaline phosphatase. In two animal models of polycystic kidney disease, the expression of Kid-1 is downregulated. The loss of expression of Kid-1 in cyst wall cells correlates with the loss of alkaline phosphatase histochemical staining. Kid-1 mRNA levels are also reduced in rodent renal cell carcinomas, another condition characterized by epithelial cell dedifferentiation and increased proliferation. We propose that Kid-1 plays an important role during the differentiation of the proximal tubule.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0002-9513
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
275
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
F928-37
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:9843910-Aging,
pubmed-meshheading:9843910-Animals,
pubmed-meshheading:9843910-Animals, Newborn,
pubmed-meshheading:9843910-Antibodies, Monoclonal,
pubmed-meshheading:9843910-COS Cells,
pubmed-meshheading:9843910-Carcinoma, Renal Cell,
pubmed-meshheading:9843910-Cell Line, Transformed,
pubmed-meshheading:9843910-DNA-Binding Proteins,
pubmed-meshheading:9843910-Epithelial Cells,
pubmed-meshheading:9843910-Epithelium,
pubmed-meshheading:9843910-Immunohistochemistry,
pubmed-meshheading:9843910-Kidney,
pubmed-meshheading:9843910-Kidney Neoplasms,
pubmed-meshheading:9843910-Kidney Tubules, Proximal,
pubmed-meshheading:9843910-Mice,
pubmed-meshheading:9843910-Polycystic Kidney Diseases,
pubmed-meshheading:9843910-RNA, Messenger,
pubmed-meshheading:9843910-Rats,
pubmed-meshheading:9843910-Rats, Sprague-Dawley,
pubmed-meshheading:9843910-Transcription Factors
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Kid-1 expression is high in differentiated renal proximal tubule cells and suppressed in cyst epithelia.
|
|
pubmed:affiliation |
Institute of Anatomy and Cell Biology I, University of Heidelberg, 69120 Heidelberg, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
