| pubmed-article:9841849 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9841849 | lifeskim:mentions | umls-concept:C0043474 | lld:lifeskim |
| pubmed-article:9841849 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:9841849 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:9841849 | lifeskim:mentions | umls-concept:C0012132 | lld:lifeskim |
| pubmed-article:9841849 | lifeskim:mentions | umls-concept:C0286738 | lld:lifeskim |
| pubmed-article:9841849 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:9841849 | lifeskim:mentions | umls-concept:C1318970 | lld:lifeskim |
| pubmed-article:9841849 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9841849 | pubmed:dateCreated | 1999-2-3 | lld:pubmed |
| pubmed-article:9841849 | pubmed:abstractText | The relationships among treatment regimens, plasma human immunodeficiency virus (HIV) RNA levels, and resistance mutations to saquinavir (codons 48 and 90) and zidovudine (codon 215) were examined in a cohort of 144 patients from the AIDS Clinical Trials Group 229 study. After 24-40 weeks of therapy, no patients who had received the two-drug combination (zidovudine plus saquinavir) had only codon 48 mutations, 45.8% had only codon 90 mutations, and 8.3% had both codon 48 and 90 mutations. Mutations developed by patients who had received the three-drug combination (zidovudine and zalcitabine plus saquinavir) were codon 48 alone in 1.4%, codon 90 alone in 33.3%, and both codons 48 and 90 in 4.2%. The difference between the groups showed a trend toward reduced mutations with three versus two drugs but did not reach significance (P=.11, two-sided chi2). Higher baseline HIV RNA levels correlated with the development of protease mutations. Mutations at codon 215 were present in 82% of all patients at baseline and in 87% after therapy. | lld:pubmed |
| pubmed-article:9841849 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9841849 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9841849 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9841849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9841849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9841849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9841849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9841849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9841849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9841849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9841849 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9841849 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9841849 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:9841849 | pubmed:author | pubmed-author:MeriganT CTC | lld:pubmed |
| pubmed-article:9841849 | pubmed:author | pubmed-author:CoombsR WRW | lld:pubmed |
| pubmed-article:9841849 | pubmed:author | pubmed-author:LawrenceJJ | lld:pubmed |
| pubmed-article:9841849 | pubmed:author | pubmed-author:CollierA CAC | lld:pubmed |
| pubmed-article:9841849 | pubmed:author | pubmed-author:EfronBB | lld:pubmed |
| pubmed-article:9841849 | pubmed:author | pubmed-author:WintersM AMA | lld:pubmed |
| pubmed-article:9841849 | pubmed:author | pubmed-author:SchapiroJ MJM | lld:pubmed |
| pubmed-article:9841849 | pubmed:author | pubmed-author:SpeckRR | lld:pubmed |
| pubmed-article:9841849 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9841849 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:9841849 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9841849 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9841849 | pubmed:pagination | 249-53 | lld:pubmed |
| pubmed-article:9841849 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:9841849 | pubmed:meshHeading | pubmed-meshheading:9841849-... | lld:pubmed |
| pubmed-article:9841849 | pubmed:meshHeading | pubmed-meshheading:9841849-... | lld:pubmed |
| pubmed-article:9841849 | pubmed:meshHeading | pubmed-meshheading:9841849-... | lld:pubmed |
| pubmed-article:9841849 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9841849 | pubmed:articleTitle | Resistance mutations to zidovudine and saquinavir in patients receiving zidovudine plus saquinavir or zidovudine and zalcitabine plus saquinavir in AIDS clinical trials group 229. | lld:pubmed |
| pubmed-article:9841849 | pubmed:affiliation | Division of Infectious Diseases, Stanford University School of Medicine, California, USA. | lld:pubmed |
| pubmed-article:9841849 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9841849 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:9841849 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9841849 | lld:pubmed |
