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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1999-2-3
|
| pubmed:abstractText |
Characterization of persons highly exposed to human immunodeficiency virus (HIV)-1 who remain uninfected may help define protective immunity. Seventeen HIV-1-seronegative Thai female sex workers (CSWs) with epidemiologic evidence of exposure to HIV-1 were studied for humoral immune responses and phenotypic and genotypic analyses of HLA class I and CCR5 allelic profiles. Infected CSWs and low-risk HIV-1-seronegative Thai women were controls. Highly exposed, persistently seronegative (HEPS) CSWs did not differ from HIV-infected CSWs in HIV risks, condom use, or sexually transmitted diseases. Significant differences were seen in humoral immune responses: gp160-specific IgA responses were detected in cervicovaginal lavage fluids in 6 of 13 HEPS CSWs but 0 of 21 seronegative subjects. All women had wild-type CCR5. HEPS CSWs were more likely to have the HLA-B18 phenotype and genotype than were matched controls (corrected P=.018). Epidemiologic exposure to HIV-1 without apparent infection, an unusual distribution of HLA class I alleles, and HIV-1 gp160-specific IgA responses suggest a biologic basis for this phenomenon.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-1899
|
| pubmed:author |
pubmed-author:ArtensteinA WAW,
pubmed-author:BeyrerCC,
pubmed-author:BirxD LDL,
pubmed-author:KhamboonruangCC,
pubmed-author:NatpratanCC,
pubmed-author:NelsonK EKE,
pubmed-author:RinkaewMM,
pubmed-author:RugpaoSS,
pubmed-author:SHAWE JEJ,
pubmed-author:StephensHH,
pubmed-author:VanCottT CTC,
pubmed-author:ZimmermanP APA
|
| pubmed:issnType |
Print
|
| pubmed:volume |
179
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
59-67
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9841823-Adolescent,
pubmed-meshheading:9841823-Adult,
pubmed-meshheading:9841823-Body Fluids,
pubmed-meshheading:9841823-Case-Control Studies,
pubmed-meshheading:9841823-Cervix Uteri,
pubmed-meshheading:9841823-Cohort Studies,
pubmed-meshheading:9841823-Female,
pubmed-meshheading:9841823-Genes, MHC Class I,
pubmed-meshheading:9841823-HIV Antibodies,
pubmed-meshheading:9841823-HIV Envelope Protein gp160,
pubmed-meshheading:9841823-HIV Infections,
pubmed-meshheading:9841823-HIV Seronegativity,
pubmed-meshheading:9841823-HIV-1,
pubmed-meshheading:9841823-Humans,
pubmed-meshheading:9841823-Immunity, Mucosal,
pubmed-meshheading:9841823-Immunoglobulin A, Secretory,
pubmed-meshheading:9841823-Prostitution,
pubmed-meshheading:9841823-Seroepidemiologic Studies,
pubmed-meshheading:9841823-Thailand,
pubmed-meshheading:9841823-Vagina
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Epidemiologic and biologic characterization of a cohort of human immunodeficiency virus type 1 highly exposed, persistently seronegative female sex workers in northern Thailand. Chiang Mai HEPS Working Group.
|
| pubmed:affiliation |
Division of Retrovirology, Walter Reed Army Institute of Research, Bethesda, MD, USA. cbeyrer@jhsph.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|