Linked Life Data

9841227

Source:http://linkedlifedata.com/resource/pubmed/id/9841227

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1998-11-17
pubmed:databankReference
pubmed:abstractText
Abnormal regulation of transcription of the beta-amyloid precursor protein (betaAPP) gene is implicated in the pathogenesis of Alzheimer's disease (AD). We have examined 17- kb genomic region which contains the 5'-flanking region (promoter), first exon and on of the betaAPP gene of the Rhesus monkey (rhbetaAPP). A predominant scription start site was tified 146 bp upstream of the translation initiation codon. Sequencing 5848 bp of 5'-flanking revealed the presence of multiple near consensus sequences for binding potential transcriptional regulatory factors, such as activator proteins (AP-1, AP-2), an apolipoprotein E-B1 element, estrogen-responsive element, heat shock element and NF-kappaB. The sequence of the rhbetaAPP promoter also contains several sites for the binding of proteins that serve as signal transducers and activators of transcription (STAT1) (GAS). The rhbetaAPP promoter is highly homologous to the human promoter, but less homologous to the rodents. The homology between human and Rhesus monkey of the further upstream region gradually decreased over its length. A region of 270 bp of the human betaAPP promoter is missing from the Rhesus monkey promoter. Structural analysis of the promoter suggests that it contains characteristics of inducible genes and sites for regulated activity by various transcription factors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0378-1119
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
217
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-64
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:9841227-Amino Acid Sequence, pubmed-meshheading:9841227-Amyloid beta-Protein Precursor, pubmed-meshheading:9841227-Animals, pubmed-meshheading:9841227-Base Sequence, pubmed-meshheading:9841227-Binding Sites, pubmed-meshheading:9841227-Cloning, Organism, pubmed-meshheading:9841227-Codon, pubmed-meshheading:9841227-Consensus Sequence, pubmed-meshheading:9841227-DNA, pubmed-meshheading:9841227-DNA Primers, pubmed-meshheading:9841227-DNA-Binding Proteins, pubmed-meshheading:9841227-Humans, pubmed-meshheading:9841227-Macaca mulatta, pubmed-meshheading:9841227-Mice, pubmed-meshheading:9841227-Models, Molecular, pubmed-meshheading:9841227-Molecular Sequence Data, pubmed-meshheading:9841227-Nucleic Acid Conformation, pubmed-meshheading:9841227-Polymerase Chain Reaction, pubmed-meshheading:9841227-Promoter Regions, Genetic, pubmed-meshheading:9841227-Rats, pubmed-meshheading:9841227-Species Specificity, pubmed-meshheading:9841227-Transcription, Genetic
pubmed:year
1998
pubmed:articleTitle
Molecular cloning of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein: structural characterization and a comparative study with other species.
pubmed:affiliation
Program in Medical Neurobiology, Institute of Psychiatric Research, Department of Psychiatry, 791 Union Drive, Indianopolis, IN 46202, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.