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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1998-12-14
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pubmed:abstractText |
HLA-DO is a non-classical MHC class II molecule presumed to play a specialized role in the antigen processing pathway. We have modeled the HLA-DO beta-chain and found its overall structure compatible with the one of DR beta. Functional studies further highlighted the similarity between these beta-chains of the class II family of proteins. Indeed, a mixed heterodimer composed of the DR alpha and a chimeric DO beta-chains presented bacterial superantigens to T cells and was shown to interact with CD4. The implications of such structural conservation for the in vivo functions of HLA-DO are discussed.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0161-5890
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
885-93
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9839557-Amino Acid Sequence,
pubmed-meshheading:9839557-Animals,
pubmed-meshheading:9839557-Antibodies, Monoclonal,
pubmed-meshheading:9839557-Antigen Presentation,
pubmed-meshheading:9839557-Cell Line,
pubmed-meshheading:9839557-Conserved Sequence,
pubmed-meshheading:9839557-Dimerization,
pubmed-meshheading:9839557-HLA-D Antigens,
pubmed-meshheading:9839557-HLA-DR Antigens,
pubmed-meshheading:9839557-Histocompatibility Antigens Class II,
pubmed-meshheading:9839557-Humans,
pubmed-meshheading:9839557-Hybridomas,
pubmed-meshheading:9839557-Mice,
pubmed-meshheading:9839557-Models, Molecular,
pubmed-meshheading:9839557-Molecular Sequence Data,
pubmed-meshheading:9839557-Protein Conformation,
pubmed-meshheading:9839557-Protein Folding,
pubmed-meshheading:9839557-Recombinant Fusion Proteins,
pubmed-meshheading:9839557-Sequence Homology, Amino Acid,
pubmed-meshheading:9839557-T-Lymphocytes,
pubmed-meshheading:9839557-Transfection
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pubmed:year |
1998
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pubmed:articleTitle |
Conserved structural features between HLA-DO beta and -DR beta.
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pubmed:affiliation |
Immunochimie Analytique, Institut Pasteur, Paris, France. thibodj@magellan.umontreal.ca
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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