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pubmed:abstractText |
A primary structural element is identified which is present in the Nef protein of immunodeficiency viruses and in the cytoplasmic domain of a regulatory T cell protein, CTLA-4. In both proteins, conserved residues that lie within this element have been shown to be important for the regulation of cellular signaling and endocytic trafficking. The structural similarity identified suggests conserved and, possibly, interactive mechanisms for Nef- and CTLA-4-dependent modulation of T cell function.
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