| pubmed-article:9839212 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9839212 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9839212 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9839212 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:9839212 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:9839212 | lifeskim:mentions | umls-concept:C0031684 | lld:lifeskim |
| pubmed-article:9839212 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:9839212 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:9839212 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:9839212 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:9839212 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9839212 | pubmed:dateCreated | 1999-2-4 | lld:pubmed |
| pubmed-article:9839212 | pubmed:abstractText | Digestion of bovine alpha s1-casein with bovine trypsin produced peptide(s) with an inhibitory effect on concanavalin A-induced proliferation of mouse spleen cells. One of these peptides was isolated from the alpha s1-casein digest following ultrafiltration, hydroxyapatite chromatography and reversed-phase HPLC, and amino acid composition and sequence analyses showed it to be sequence 59-79 from the phosphoserine-rich region of alpha s1-casein. The isolated peptide significantly inhibited the concanavalin A-induced proliferation of mouse spleen cells and rabbit Peyer's patch cells, whereas it enhanced the lipopolysaccharide- and phytohaemagglutinin-induced proliferation of both cells. The peptide displayed mitogenic activity in the cell cultures without the commercial mitogen, and significantly enhanced immunoglobulin production. Moreover, residues 1-25 from the phosphoserine-rich region of bovine beta-casein had a similar effect on the proliferation of mouse spleen cells and rabbit Peyer's patch cells stimulated or not stimulated by the commercial mitogen. These results indicate that caseinophosphopeptides may act as a humoral immunostimulator in cell cultures. | lld:pubmed |
| pubmed-article:9839212 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9839212 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9839212 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9839212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9839212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9839212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9839212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9839212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9839212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9839212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9839212 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9839212 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9839212 | pubmed:issn | 0022-0299 | lld:pubmed |
| pubmed-article:9839212 | pubmed:author | pubmed-author:OtaniHH | lld:pubmed |
| pubmed-article:9839212 | pubmed:author | pubmed-author:HigashiyamaSS | lld:pubmed |
| pubmed-article:9839212 | pubmed:author | pubmed-author:HataII | lld:pubmed |
| pubmed-article:9839212 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9839212 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:9839212 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9839212 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9839212 | pubmed:pagination | 569-78 | lld:pubmed |
| pubmed-article:9839212 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:meshHeading | pubmed-meshheading:9839212-... | lld:pubmed |
| pubmed-article:9839212 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9839212 | pubmed:articleTitle | Identification of a phosphopeptide in bovine alpha s1-casein digest as a factor influencing proliferation and immunoglobulin production in lymphocyte cultures. | lld:pubmed |
| pubmed-article:9839212 | pubmed:affiliation | Laboratory of Food Bioscience, Faculty of Agriculture, Shinshu University, Nagano-ken, Japan. | lld:pubmed |
| pubmed-article:9839212 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9839212 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
