Linked Life Data

9839077

Source:http://linkedlifedata.com/resource/pubmed/id/9839077

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-3-24
pubmed:abstractText
Cell-cell and cell-matrix contacts are dependent on cell surface density, localization, and avidity state of adhesion molecules. These adhesion molecules are involved in all steps of the leukocyte's adhesion process. Selectins, molecules of the immunoglobulin superfamily, and integrins are necessary for an initial tethering, triggering, firm attachment, and transendothelial migration of leukocytes. Hormones, cytokines, other pro-inflammatory agents, and shedded receptors like the LPS-receptor significantly alter the adhesion process. Infectious and noninfectious inflammatory processes are capable of inducing an altered adhesion of leukocytes to endothelial cells. The result is a preferential homing of leukocytes to sites of inflammation. Acute bouts of exercise may induce a release or secretion of many of the aforementioned substances involved in the adhesion process. The acute immune response to exercise is strongly influenced by the activation of the sympathetic nervous system and the hypothalamo-pituitary-adrenal axis. During the first 10-30 min of exercise an almost maximal increase of T and B lymphocytes, monocytes, and NK cells from the marginal pool into the blood circulation is induced. This demargination of cells is likely an effect mediated by beta 2 adrenergic receptors and probably due to a change of the avidity state of adhesion molecules. Strenuous exercise is associated with an increase of serum cortisol resulting in a delayed neutrocytosis and lymphocytopenia. Both phenomena are due to altered circulation patterns. It will be discussed how far adhesion molecules might contribute to this effect. Furthermore an evaluation of contradicting experimental results about surface expression of selectins and integrins will be provided.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0008-4212
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
512-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Adhesion molecules during immune response to exercise.
pubmed:affiliation
Institute for Sports and Preventive Medicine, Faculty of Medicine, University of the Saarland, Saarbrücken, Germany. gabriel@rz.uni-sb.de
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't