Linked Life Data

9838879

Source:http://linkedlifedata.com/resource/pubmed/id/9838879

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1998-12-23
pubmed:abstractText
Vascular contractile response to phenylephrine and potassium chloride were examined in strips of isolated thoracic aorta from non-diabetic monkeys with and without intact endothelium exposed to glucose (5.5 mM; control) and (11 mM; high) concentration. Acetylcholine causes relaxation in isolated aortic strips with intact endothelial cells while it causes contraction in aortic strips with damaged endothelial cells. In preparations with intact and damaged endothelium, there was a significant increase in the maximal contractile response to potassium chloride when added cumulatively, on exposure to elevated glucose (11 mM) concentration as compared to control. It was also observed that relaxant response to acetylcholine and sodium nitroprusside in control (5.5 mM) and high glucose (44 mM) concentration. Endothelium-dependent relaxation to acetylcholine decreased significantly in the presence of 44 mM glucose. In preparation without endothelium, contraction caused by acetylcholine increased in the presence of glucose (44 mM). Direct smooth muscle relaxation to sodium nitroprusside remained unchanged in aortic strips with and without endothelium. Relaxation response to sodium nitroprusside decreased in strips with damaged endothelium on exposure to high glucose when compared to control glucose.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0019-5189
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
780-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Effect of elevated glucose on contractile and relaxant response of aortic strips in Indian bonnet monkey (Macaca radiata radiata).
pubmed:affiliation
Department of Pharmacology, Christian Medical College, Bagayam, Vellore, India.
pubmed:publicationType
Journal Article, In Vitro