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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-1-21
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pubmed:databankReference |
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pubmed:abstractText |
Pineal melatonin synthesis (serotonin --> N-acetylserotonin --> melatonin) is severely compromised in most inbred strains of mice, in many cases because serotonin is not acetylated by serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT). We have found that in the C57BL/6J strain, AANAT mRNA encodes a severely truncated AANAT protein, because a pseudo-exon containing a stop codon is spliced in. This is the first identification of a natural mutation which knocks down melatonin synthesis. The decrease in melatonin signaling may have been a selective factor in the development of laboratory strains of mice because melatonin can inhibit reproduction and modify circadian rhythmicity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0169-328X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1998 Elsevier Science B.V.
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-97
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9838107-Animals,
pubmed-meshheading:9838107-Arylamine N-Acetyltransferase,
pubmed-meshheading:9838107-Blotting, Northern,
pubmed-meshheading:9838107-Brain,
pubmed-meshheading:9838107-Circadian Rhythm,
pubmed-meshheading:9838107-DNA, Complementary,
pubmed-meshheading:9838107-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:9838107-Introns,
pubmed-meshheading:9838107-Melatonin,
pubmed-meshheading:9838107-Mice,
pubmed-meshheading:9838107-Mice, Inbred C3H,
pubmed-meshheading:9838107-Mice, Inbred C57BL,
pubmed-meshheading:9838107-Mice, Knockout,
pubmed-meshheading:9838107-Molecular Sequence Data,
pubmed-meshheading:9838107-Pineal Gland,
pubmed-meshheading:9838107-RNA, Messenger,
pubmed-meshheading:9838107-RNA Splicing,
pubmed-meshheading:9838107-Recombinant Proteins,
pubmed-meshheading:9838107-Sequence Homology, Amino Acid,
pubmed-meshheading:9838107-Species Specificity
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pubmed:year |
1998
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pubmed:articleTitle |
Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase.
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pubmed:affiliation |
Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article
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