Linked Life Data

9835390

Source:http://linkedlifedata.com/resource/pubmed/id/9835390

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1999-2-11
pubmed:abstractText
In the present article a number of comparative lesion studies in two inbred strains of mice (C57BL/6 and DBA/2) with different levels of radial maze performance are reviewed. The effects of lesions in several brain areas on maze learning were investigated, thus revealing strain differences in the neural circuitry subserving spatial cognition. Results showed that the hippocampus and parietal cortex appear to be involved in the control of radial maze learning in both C57 and DBA mice, although in a strain-dependent fashion. Lesions in other structures such as the medial frontal cortex and the amygdala only affected spatial learning in the C57 strain. Lastly, the results showed some improvement in radial maze performance in DBA mice with nucleus accumbens lesions. The data highlight the variability in the neural mechanisms subserving well-differentiated levels of spatial performance. The contribution of inbred mice to our general understanding of the neural basis of spatial cognition is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0014-4819
pubmed:author
pubmed:issnType
Print
pubmed:volume
123
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
36-44
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
What do comparative studies of inbred mice add to current investigations on the neural basis of spatial behaviors?
pubmed:affiliation
Dipartimento di Psicologia, Rome, Italy. arnaud@uniroma1.it
pubmed:publicationType
Journal Article, Comparative Study, Review