rdf:type |
|
lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1999-2-18
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pubmed:abstractText |
Methanolic extracts prepared from the leaves of Lantana camara have been found to inhibit human thrombin. An assay, in which thrombin activity is measured as a function of clot formation from fibrinogen, was used to guide the fractionation and purification of five principal active constituents (1-5), which were all characterized as 5,5-trans-fused cyclic lactone-containing euphane triterpenes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0163-3864
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pubmed:author |
pubmed-author:DixC JCJ,
pubmed-author:FarthingJ EJE,
pubmed-author:FosterGG,
pubmed-author:HayesM VMV,
pubmed-author:HollandSS,
pubmed-author:LangS LSL,
pubmed-author:LewisJ AJA,
pubmed-author:MaloneJ WJW,
pubmed-author:NobleDD,
pubmed-author:NobleH MHM,
pubmed-author:O'NeillM JMJ,
pubmed-author:PAPEKK,
pubmed-author:SidebottomP JPJ
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1328-31
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9834145-Carbohydrate Sequence,
pubmed-meshheading:9834145-Crystallography, X-Ray,
pubmed-meshheading:9834145-Fibrinogen,
pubmed-meshheading:9834145-Humans,
pubmed-meshheading:9834145-Molecular Sequence Data,
pubmed-meshheading:9834145-Plant Extracts,
pubmed-meshheading:9834145-Plant Leaves,
pubmed-meshheading:9834145-Plants, Medicinal,
pubmed-meshheading:9834145-Spectrophotometry, Infrared,
pubmed-meshheading:9834145-Spectrophotometry, Ultraviolet,
pubmed-meshheading:9834145-Thrombin,
pubmed-meshheading:9834145-Triterpenes
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pubmed:year |
1998
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pubmed:articleTitle |
Isolation of translactone-containing triterpenes with thrombin inhibitory activities from the leaves of Lantana camara.
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pubmed:affiliation |
GlaxoWellcome Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK. mjon7483@glaxowellcome.co.uk
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pubmed:publicationType |
Journal Article
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