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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1998-12-9
|
| pubmed:abstractText |
A novel model was developed to characterize the time-varying clearance of recombinant interleukin-2 (IL-2). Sixty-eight patients with human immunodeficiency virus infection received 83 cycles of IL-2 either by continuous infusion or by subcutaneous injection for 5 days. IL-2 concentrations after intravenous infusions peaked at 24 hours and then declined by 55% to 78% during the remainder of the infusion. Soluble IL-2 receptors increased greater than 10-fold before gradually returning to baseline. Subcutaneous administration showed a dose-dependent decrease in area under the concentration-time curve (AUC) between days 1 and 5. A model was developed in 9 patients who had IL-2 concentrations and soluble IL-2 receptors determined by ELISA. Concentrations were fitted by an indirect stimulatory pharmacodynamic model. An additional 59 patients with only IL-2 concentrations were fitted to a simplified empiric model. Both models provided an overall r2 of 0.99 for the plot of observed versus fitted concentrations. The time-dependent increase in IL-2 clearance, likely receptor-mediated, was well described with use of an indirect-effects pharmacokinetic-pharmacodynamic model.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0009-9236
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
64
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
492-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9834041-Adult,
pubmed-meshheading:9834041-Aged,
pubmed-meshheading:9834041-Area Under Curve,
pubmed-meshheading:9834041-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:9834041-Female,
pubmed-meshheading:9834041-HIV Infections,
pubmed-meshheading:9834041-Humans,
pubmed-meshheading:9834041-Infusions, Intravenous,
pubmed-meshheading:9834041-Injections, Subcutaneous,
pubmed-meshheading:9834041-Interleukin-2,
pubmed-meshheading:9834041-Male,
pubmed-meshheading:9834041-Middle Aged,
pubmed-meshheading:9834041-Models, Theoretical,
pubmed-meshheading:9834041-Receptors, Interleukin-2,
pubmed-meshheading:9834041-Time Factors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Pharmacokinetic modeling of recombinant interleukin-2 in patients with human immunodeficiency virus infection.
|
| pubmed:affiliation |
Department of Pharmacy, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. spisc@nih.gov
|
| pubmed:publicationType |
Journal Article
|