Linked Life Data

9832990

Source:http://linkedlifedata.com/resource/pubmed/id/9832990

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-12-15
pubmed:abstractText
Insufficient research has been carried out on the effects of repeated treatments with psychostimulants on agonistic behaviour. These effects were studied in mice using different schedules of administration and employing a low dose of amphetamine (1.5 mg/kg) which did not produce significant motor disruptions. After two injections, with a 5-day interval between them, antiaggressive effects (decreases in attack and increases in avoidance/flight behaviour) were found, which were similar to those observed after acute administration, in addition to an increase in defence. With a higher number of injections but with shorter intervals (daily treatment) the effects diminished and even disappeared. Tolerance to the antiaggressive as well as to motor effects (digging and non-social exploration) was found after 7 daily injections. The appearance of avoidance, defensive and flight behaviours in this model supports the inclusion of agonistic behaviour in rodent models of psychoses and highlights the importance of analysing the effects of different characteristics of the repeated treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0955-8810
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
309-18
pubmed:dateRevised
2009-7-7
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effects of repeated administration of d-amphetamine on agonistic behaviour of isolated male mice.
pubmed:affiliation
Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castellón, Spain.
pubmed:publicationType
Journal Article