Linked Life Data

9832067

Source:http://linkedlifedata.com/resource/pubmed/id/9832067

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-2-3
pubmed:abstractText
HLA-DR antigens a side from their antigen-presenting function have recently been shown to allow for transmembrane signaling. Findings in several models suggest that such a signaling function may occur in hematopoietic tissues. Signals generated via HLA-DR result in upregulation of tumor necrosis factor alpha (TNF-alpha) and nitric oxide as well as an enhanced expression of Fas and its natural ligand (Fas-L), all molecules associated with programmed cell death (apoptosis). While a role of HLA-DR in hematopoietic failure remains hypothetical, the data presented here can be accommodated into a model of hematopoietic failure initiated by HLA-DR mediated signals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-069X
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
285-91
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
MHC class II and negative regulators of hematopoiesis.
pubmed:affiliation
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review