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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1999-1-12
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pubmed:databankReference |
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pubmed:abstractText |
The granaticins are members of the benzoisochromanequinone class of aromatic polyketides, the best known member of which is actinorhodin made by Streptomyces coelicolor A3(2). Genetic analysis of this class of compounds has played a major role in the development of hypotheses about the way in which aromatic polyketide synthases (PKSs) control product structure. Although the granaticin nascent polyketide is identical to that of actinorhodin, post-PKS steps involve different pyran-ring stereochemistry and glycosylation. Comparison of the complete gene clusters for the two metabolites is therefore of great interest.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
647-59
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9831526-Amino Acid Sequence,
pubmed-meshheading:9831526-Chromatography, High Pressure Liquid,
pubmed-meshheading:9831526-Cosmids,
pubmed-meshheading:9831526-DNA, Bacterial,
pubmed-meshheading:9831526-Glycosylation,
pubmed-meshheading:9831526-Molecular Sequence Data,
pubmed-meshheading:9831526-Multienzyme Complexes,
pubmed-meshheading:9831526-Multigene Family,
pubmed-meshheading:9831526-Naphthoquinones,
pubmed-meshheading:9831526-Open Reading Frames,
pubmed-meshheading:9831526-Plasmids,
pubmed-meshheading:9831526-RNA, Transfer,
pubmed-meshheading:9831526-Recombinant Proteins,
pubmed-meshheading:9831526-Streptomyces
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pubmed:year |
1998
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pubmed:articleTitle |
The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22: sequence analysis and expression in a heterologous host.
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pubmed:affiliation |
Department of Genetics John Innes Centre Norwich Research Park Colney Norwich NR4 7UH UK.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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