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pubmed-article:9828104pubmed:abstractTextExposure of the human leukemic cell line (HL-60) to 1 microM retinoic acid (RA) induces in vitro granulopoiesis, including the development of lobulated nuclei. Ultrastructural studies, presented here, demonstrate the formation of extensive quantities of nuclear envelope-limited chromatin sheets (ELCS), in addition to nuclear lobulation, following treatment with RA. ELCS contain DNA, as shown by the Feulgen-like electron microscope stain osmium ammine-B. Lamin B was demonstrated in ELCS by immunoelectron microscopy with colloidal gold-labeled antibody. Formation of ELCS occurred in Bcl2-overexpressing HL-60 cell sublines with suppressed apoptotic cell death, indicating separable mechanisms for ELCS formation and apoptosis. Immunofluorescent and immunoblotting procedures demonstrated modulations in the amounts and distribution of nuclear envelope-associated components. Total amounts of lamins A/C and cytoplasmic vimentin were reduced by RA treatment. The amounts of lamin B, lamin B receptor (LBR), and lamina-associated polypeptide 2 (LAP2) did not exhibit significant quantitative changes, but acquired heterogeneous staining patterns on the nuclear envelope. RA induced the appearance of low-molecular-weight LBR-related proteins. This study demonstrated the parallel induction of lobulated nuclei and of ELCS and the modulation of nuclear envelope components following exposure of HL-60 to retinoic acid.lld:pubmed
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pubmed-article:9828104pubmed:authorpubmed-author:HerrmannHHlld:pubmed
pubmed-article:9828104pubmed:authorpubmed-author:OlinsD EDElld:pubmed
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pubmed-article:9828104pubmed:copyrightInfoCopyright 1998 Academic Press.lld:pubmed
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pubmed-article:9828104pubmed:volume245lld:pubmed
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pubmed-article:9828104pubmed:pagination91-104lld:pubmed
pubmed-article:9828104pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9828104pubmed:articleTitleRetinoic acid induction of nuclear envelope-limited chromatin sheets in HL-60.lld:pubmed
pubmed-article:9828104pubmed:affiliationFoundation for Blood Research, 69 US Route One, Scarborough, Maine, 04070-0190, USA.lld:pubmed
pubmed-article:9828104pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9828104pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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