Linked Life Data

9827051

Source:http://linkedlifedata.com/resource/pubmed/id/9827051

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-12-14
pubmed:abstractText
The independent effects of decreased food intake and diabetic hyperglycemia on serum GH, serum IGF-I and tissue IGF-I expression were examined in young streptozotocin-diabetic pigs. Each of three treatments (control, diabetic, and insulin-treated diabetic) were represented within three levels of regulated food intake (FI) provided as three meals per day equivalent to 100, 50, and 10% of the voluntary FI consumed by the untreated diabetics. Reduction of food intake was associated with decreased body weight gains, decreased serum IGF-I concentrations, and increased serum GH concentrations. Nutrient restriction also tended to decrease the relative abundance of IGF-I mRNA in liver and skeletal muscle. Diabetic pigs with hyperglycemia and hypoinsulinemia had higher serum concentrations of IGF-I than pair-fed controls, but exogenous insulin treatment of these diabetic pigs increased serum IGF-I even further and also tended to increase the relative abundance of IGF-I mRNA in liver and skeletal muscle. When the statistical effects of reduced FI were eliminated, neither the present form of diabetes nor exogenous insulin affected serum GH. In summary, diabetes-induced changes in IGF-I in these pigs depended primarily on the reduced level of food intake occurring in these hypoinsulinemic, hyperglycemic subjects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1367-8280
pubmed:author
pubmed:issnType
Print
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
357-63
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Independent effects of food intake and insulin status on insulin-like growth factor-I in young pigs.
pubmed:affiliation
Lilly Research Laboratories, Greenfield, IN 46140, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't