| pubmed-article:9826725 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9826725 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:9826725 | lifeskim:mentions | umls-concept:C0599779 | lld:lifeskim |
| pubmed-article:9826725 | lifeskim:mentions | umls-concept:C0034838 | lld:lifeskim |
| pubmed-article:9826725 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:9826725 | pubmed:dateCreated | 1998-12-28 | lld:pubmed |
| pubmed-article:9826725 | pubmed:abstractText | To investigate the contribution of individual serotonin (5-hydroxytryptamine; 5-HT) receptors to mood control, we have used homologous recombination to generate mice lacking specific serotonergic receptor subtypes. In the present report, we demonstrate that mice without 5-HT1A receptors display decreased exploratory activity and increased fear of aversive environments (open or elevated spaces). 5-HT1A knockout mice also exhibited a decreased immobility in the forced swim test, an effect commonly associated with antidepressant treatment. Although 5-HT1A receptors are involved in controlling the activity of serotonergic neurons, 5-HT1A knockout mice had normal levels of 5-HT and 5-hydroxyindoleacetic acid, possibly because of an up-regulation of 5-HT1B autoreceptors. Heterozygote 5-HT1A mutants expressed approximately one-half of wild-type receptor density and displayed intermediate phenotypes in most behavioral tests. These results demonstrate that 5-HT1A receptors are involved in the modulation of exploratory and fear-related behaviors and suggest that reductions in 5-HT1A receptor density due to genetic defects or environmental stressors might result in heightened anxiety. | lld:pubmed |
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| pubmed-article:9826725 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9826725 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9826725 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9826725 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9826725 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9826725 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9826725 | pubmed:author | pubmed-author:HenRR | lld:pubmed |
| pubmed-article:9826725 | pubmed:author | pubmed-author:MendelsohnMM | lld:pubmed |
| pubmed-article:9826725 | pubmed:author | pubmed-author:MARSP HPH | lld:pubmed |
| pubmed-article:9826725 | pubmed:author | pubmed-author:BrunnerDD | lld:pubmed |
| pubmed-article:9826725 | pubmed:author | pubmed-author:MannJ JJJ | lld:pubmed |
| pubmed-article:9826725 | pubmed:author | pubmed-author:BlierPP | lld:pubmed |
| pubmed-article:9826725 | pubmed:author | pubmed-author:RambozSS | lld:pubmed |
| pubmed-article:9826725 | pubmed:author | pubmed-author:OostingRR | lld:pubmed |
| pubmed-article:9826725 | pubmed:author | pubmed-author:AmaraD ADA | lld:pubmed |
| pubmed-article:9826725 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9826725 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:9826725 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:9826725 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9826725 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9826725 | pubmed:pagination | 14476-81 | lld:pubmed |
| pubmed-article:9826725 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9826725 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9826725 | pubmed:articleTitle | Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. | lld:pubmed |
| pubmed-article:9826725 | pubmed:affiliation | Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032, USA. | lld:pubmed |
| pubmed-article:9826725 | pubmed:publicationType | Journal Article | lld:pubmed |
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