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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
1998-12-28
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pubmed:abstractText |
To investigate the contribution of individual serotonin (5-hydroxytryptamine; 5-HT) receptors to mood control, we have used homologous recombination to generate mice lacking specific serotonergic receptor subtypes. In the present report, we demonstrate that mice without 5-HT1A receptors display decreased exploratory activity and increased fear of aversive environments (open or elevated spaces). 5-HT1A knockout mice also exhibited a decreased immobility in the forced swim test, an effect commonly associated with antidepressant treatment. Although 5-HT1A receptors are involved in controlling the activity of serotonergic neurons, 5-HT1A knockout mice had normal levels of 5-HT and 5-hydroxyindoleacetic acid, possibly because of an up-regulation of 5-HT1B autoreceptors. Heterozygote 5-HT1A mutants expressed approximately one-half of wild-type receptor density and displayed intermediate phenotypes in most behavioral tests. These results demonstrate that 5-HT1A receptors are involved in the modulation of exploratory and fear-related behaviors and suggest that reductions in 5-HT1A receptor density due to genetic defects or environmental stressors might result in heightened anxiety.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-1359573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-1663620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-1796057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-2137943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-2423050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-3041227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-559941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-6225026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-6230136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-7557817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-7638165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-7815360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-7940983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-8091214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-8122960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-8127420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-8539307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-8539333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-8542298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-8728533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-8728550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-8742487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-8764667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-8768728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-8788530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-9408187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-9693388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9826725-9860934
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14476-81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9826725-Animals,
pubmed-meshheading:9826725-Anxiety Disorders,
pubmed-meshheading:9826725-Autoradiography,
pubmed-meshheading:9826725-Brain,
pubmed-meshheading:9826725-Disease Models, Animal,
pubmed-meshheading:9826725-Female,
pubmed-meshheading:9826725-Humans,
pubmed-meshheading:9826725-Male,
pubmed-meshheading:9826725-Mice,
pubmed-meshheading:9826725-Mice, Inbred C57BL,
pubmed-meshheading:9826725-Mice, Inbred Strains,
pubmed-meshheading:9826725-Mice, Knockout,
pubmed-meshheading:9826725-Motor Activity,
pubmed-meshheading:9826725-Neurons,
pubmed-meshheading:9826725-Receptors, Serotonin,
pubmed-meshheading:9826725-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:9826725-Recombination, Genetic,
pubmed-meshheading:9826725-Serotonin,
pubmed-meshheading:9826725-Tritium
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pubmed:year |
1998
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pubmed:articleTitle |
Serotonin receptor 1A knockout: an animal model of anxiety-related disorder.
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pubmed:affiliation |
Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032, USA.
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pubmed:publicationType |
Journal Article
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