Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1999-1-7
pubmed:abstractText
Mycosis fungoides (MF) and Sézary syndrome (SS) are closely related cutaneous T-cell lymphomas, which differ in several clinical aspects. We compared histological and immunophenotypical features of these two entities, which could be implicated in the dermotropism and epidermotropism, characteristic for both of them. Thirteen biopsy specimens from patients with established plaque-stage MF and 13 from SS patients were examined retrospectively, and 21 histological criteria were assessed. Further, 9 cryosections from MF lesions and 9 from SS lesions were stained for LFA, ICAM1, CD40, CD40-ligand, CD28, CD80, CTLA-4, CD86, FAS, FAS-ligand, CLA and CD15s. The only histological criteria that showed persistent differences were acanthosis (in 12 of 13 SS and in 7 of 13 MF specimens) and Pautrier collections (detected in 6 SS and 11 MF biopsies). Patterns of staining with the antibodies mentioned above were found to be similar. Our results indicate that these interaction molecules seem to be involved in the pathogenesis of MF and SS, but their immunohistochemical distribution does not contribute to the differentiation between the two entities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD15, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation..., http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm, http://linkedlifedata.com/resource/pubmed/chemical/CD40 Ligand, http://linkedlifedata.com/resource/pubmed/chemical/CD86 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CTAGE1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen, http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein, http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates, http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1, http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated..., http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/abatacept
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0303-6987
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
407-12
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:9826165-Adult, pubmed-meshheading:9826165-Aged, pubmed-meshheading:9826165-Aged, 80 and over, pubmed-meshheading:9826165-Antigens, CD, pubmed-meshheading:9826165-Antigens, CD15, pubmed-meshheading:9826165-Antigens, CD28, pubmed-meshheading:9826165-Antigens, CD40, pubmed-meshheading:9826165-Antigens, CD80, pubmed-meshheading:9826165-Antigens, CD86, pubmed-meshheading:9826165-Antigens, Differentiation, pubmed-meshheading:9826165-Antigens, Differentiation, T-Lymphocyte, pubmed-meshheading:9826165-Antigens, Neoplasm, pubmed-meshheading:9826165-CD40 Ligand, pubmed-meshheading:9826165-CTLA-4 Antigen, pubmed-meshheading:9826165-Fas Ligand Protein, pubmed-meshheading:9826165-Female, pubmed-meshheading:9826165-Humans, pubmed-meshheading:9826165-Immunoconjugates, pubmed-meshheading:9826165-Immunohistochemistry, pubmed-meshheading:9826165-Intercellular Adhesion Molecule-1, pubmed-meshheading:9826165-Lymphocyte Function-Associated Antigen-1, pubmed-meshheading:9826165-Male, pubmed-meshheading:9826165-Membrane Glycoproteins, pubmed-meshheading:9826165-Middle Aged, pubmed-meshheading:9826165-Mycosis Fungoides, pubmed-meshheading:9826165-Sezary Syndrome, pubmed-meshheading:9826165-Skin, pubmed-meshheading:9826165-Skin Neoplasms
pubmed:year
1998
pubmed:articleTitle
Comparative analysis of histological and immunohistological features in mycosis fungoides and Sézary syndrome.
pubmed:affiliation
Department of Dermatology, University Hospital, Zürich, Switzerland.
pubmed:publicationType
Journal Article, Comparative Study