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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-12-10
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pubmed:abstractText |
The highly conserved ATPase p97, a member of the AAA-ATPases, is found in a complex with its co-factor p47 in rat liver cytosol. Previously it had been shown that p97-mediated reassembly of Golgi cisternae from mitotic Golgi fragments requires p47 which mediates the binding of p97 to a Golgi t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment factor receptor), syntaxin 5. Here we show that it also suppresses the ATPase activity of p97 by up to 85% in a dose-dependent and saturable manner suggesting that it has other roles in the membrane fusion cycle.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
437
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
255-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9824302-Adenosine Triphosphatases,
pubmed-meshheading:9824302-Animals,
pubmed-meshheading:9824302-Carrier Proteins,
pubmed-meshheading:9824302-Cytosol,
pubmed-meshheading:9824302-Enzyme Activation,
pubmed-meshheading:9824302-Liver,
pubmed-meshheading:9824302-Membrane Fusion,
pubmed-meshheading:9824302-Membrane Proteins,
pubmed-meshheading:9824302-Protein Binding,
pubmed-meshheading:9824302-Rats,
pubmed-meshheading:9824302-Soluble N-Ethylmaleimide-Sensitive Factor Attachment...,
pubmed-meshheading:9824302-Vesicular Transport Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97.
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pubmed:affiliation |
Cell Biology Laboratory, Imperial Cancer Research Fund, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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